Human ribosome binding protein 1 homolog 180kDa (dog) ELISA Kit | RRBP1 elisa kit

Human Ribosome-binding protein 1, RRBP1 ELISA Kit

Cat. Num. AAA9329000

• Gene Names: RRBP1; RRp; hES; ES130; ES/130
• Reactivity: Human
• Synonyms: ribosome binding protein 1 homolog 180kDa (dog); Human Ribosome-binding protein 1; RRBP1 ELISA Kit; Human Ribosome-binding protein 1 (RRBP1) ELISA kit; DKFZp586A1420; ES/130; ES130; FLJ36146; MGC157720; MGC157721; hES; ribosome binding protein 1; RRBP1 elisa kit

• Reactivity: Human

• Assay Type: Quantitative Sandwich
• Detection Range: 31.2ng/ml-1000ng/ml
• Sensitivity: 5.0ng/ml
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for RRBP1 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or test applications! This kit is intended to be used for determine the level of RRBP1 (hereafter termed "analyte") in undiluted original Human serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 110611218
• NCBI GeneID: 6238
• NCBI Accession #: NP_001036041.1
• NCBI GenBank Nucleotide #: NM_001042576.1
• UniProt Accession #: Q9P2E9; O75300; O75301; Q5W165; Q96SB2; Q9BWP1; Q9H476; A2A2S6; A6NCN6
• Molecular Weight: 152,472 Da
• NCBI Official Full Name: ribosome-binding protein 1
• NCBI Official Synonym Full Names: ribosome binding protein 1
• NCBI Official Symbol: RRBP1
• NCBI Official Synonym Symbols: RRp; hES; ES130; ES/130
• NCBI Protein Information: ribosome-binding protein 1; ES/130-related protein; ribosome receptor protein; 180 kDa ribosome receptor homolog; ribosome binding protein 1 homolog 180kDa (dog)
• UniProt Protein Name: Ribosome-binding protein 1
• Protein Family: Ribosome-binding protein
• UniProt Gene Name: RRBP1
• UniProt Synonym Gene Names: KIAA1398; RRp
• UniProt Entry Name: RRBP1_HUMAN

NCBI Description

This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12. [provided by RefSeq, Apr 2012]

Uniprot Description

RRBP1: a single-pass type III membrane protein of the rough endoplasmic reticulum membrane. Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. Associated with the unfolded protein response (UPR) and has anti-apoptotic activity. Knockdown of RRBP1 induces ER stress, and is associated with a significant reduction in the expression of glucose-regulated protein 78 (GRP78). GRP78 regulates the UPR, is widely upregulated in cancer, and plays an important role in chemotherapy resistance in some cancers. Upregulated in many cancers: overexpressed in a high proportion of breast carcinoma cases tested, and is highly expressed in lung cancer tissue compared with adjacent normal tissues. Because RRBP1 appears to play a role in tumor cell survival, it may be a candidate for new targeted therapeutics. Three human isoforms are produced by alternative splicing.

Protein type: Translation; Membrane protein, integral; Ribosomal

Chromosomal Location of Human Ortholog: 20p12

Cellular Component: membrane; endoplasmic reticulum; integral to endoplasmic reticulum membrane; ribosome

Molecular Function: receptor activity

Biological Process: osteoblast differentiation; protein transport; translation