40S ribosomal protein S7 (RPS7) Recombinant Protein | RPS7 recombinant protein

Recombinant Human 40S ribosomal protein S7 (RPS7)

Cat. Num. AAA957934

• Gene Names: RPS7; S7; DBA8
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: 40S ribosomal protein S7 (RPS7); Recombinant Human 40S ribosomal protein S7 (RPS7); 40S ribosomal protein S7; RPS7 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-194, Full length protein
• Sequence: MFSSSAKIVKPNGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRKAIIIFVPVPQLKSFQKIQVRLVRELEKKFSGKHVVFIAQRRILPKPTRKSRTKNKQKRPRSRTLTAVHDAILEDLVFPSEIVGKRIRVKLDGSRLIKVHLDKAQQNNVEHKVETFSGVYKKLTGKDVNFEFPEFQL
• Sequence Length: 194

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Testing Data

NCBI and Uniprot Product Information

• NCBI GI #: 4506741
• NCBI GeneID: 6201
• NCBI Accession #: NP_001002.1
• NCBI GenBank Nucleotide #: NM_001011.3
• UniProt Accession #: P62081; P23821; P24818; Q57Z92; Q6IPH1
• Molecular Weight: 22,127 Da
• NCBI Official Full Name: 40S ribosomal protein S7
• NCBI Official Synonym Full Names: ribosomal protein S7
• NCBI Official Symbol: RPS7
• NCBI Official Synonym Symbols: S7; DBA8
• NCBI Protein Information: 40S ribosomal protein S7
• UniProt Protein Name: 40S ribosomal protein S7
• Protein Family: 40S ribosomal protein
• UniProt Gene Name: RPS7
• UniProt Entry Name: RS7_HUMAN

NCBI Description

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Uniprot Description

RPS7: Required for rRNA maturation. Defects in RPS7 are the cause of Diamond-Blackfan anemia type 8 (DBA8). DBA8 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Belongs to the ribosomal protein S7e family.

Protein type: Ribosomal; Translation

Chromosomal Location of Human Ortholog: 2p25

Cellular Component: small subunit processome; focal adhesion; membrane; cytoplasm; nucleolus; microtubule organizing center; ribosome; nucleus; cytosol; ribonucleoprotein complex

Molecular Function: protein binding; structural constituent of ribosome; RNA binding

Biological Process: SRP-dependent cotranslational protein targeting to membrane; translation; viral reproduction; translational termination; viral infectious cycle; ribosomal small subunit biogenesis and assembly; translational elongation; cellular protein metabolic process; mRNA catabolic process, nonsense-mediated decay; translational initiation; viral transcription; gene expression; rRNA processing

Disease: Diamond-blackfan Anemia 8