RNA pyrophosphohydrolase (rppH) Recombinant Protein | rppH recombinant protein
Recombinant Escherichia coli RNA pyrophosphohydrolase (rppH)
NCBI and Uniprot Product Information
NCBI Description
Nudix hydrolase. [More information is available at EcoGene: EG13091]. Mutations disrupting YgdP suppress the temperature-sensitivity of degP null mutants and mirror the effects of mutation in PrlF . [More information is available at EcoCyc: G7459].
Uniprot Description
Master regulator of 5'-end-dependent mRNA decay (PubMed:18202662). Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (PubMed:18202662). Preferentially hydrolyzes diadenosine penta-phosphate with ATP as one of the reaction products (PubMed:11479323). Also able to hydrolyze diadenosine hexa- and tetra-phosphate (PubMed:11479323). Has no activity on diadenosine tri-phosphate, ADP-ribose, NADH and UDP-glucose (PubMed:11479323). In an RNase PH (rph) wild-type strain background, RppH is not required for maturation of tRNAs; however, strains with the truncated rph allele (for example K12 W1485 and its derivatives MG1655 and W3110) require RppH for maturation of certain monocistronic tRNAs with short (<5 nucleotides) leader sequences (PubMed:28808133). In the meningitis causing strain E.coli K1, has been shown to play a role in HBMEC (human brain microvascular endothelial cells) invasion in vitro (PubMed:10760174).
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Product Notes
The rppH rpph (Catalog #AAA1195361) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-176, full length protein. The amino acid sequence is listed below: MIDDDGYRPN VGIVICNRQG QVMWARRFGQ HSWQFPQGGI NPGESAEQAM YRELFEEVGL SRKDVRILAS TRNWLRYKLP KRLVRWDTKP VCIGQKQKWF LLQLVSGDAE INMQTSSTPE FDGWRWVSYW YPVRQVVSFK RDVYRRVMKE FASVVMSLQE NTPKPQNASA YRRKRG. It is sometimes possible for the material contained within the vial of "RNA pyrophosphohydrolase (rppH), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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