Rho-associated protein kinase 2 (Rock2) Recombinant Protein | Rock2 recombinant protein

Recombinant Mouse Rho-associated protein kinase 2 (Rock2) , partial

Cat. Num. AAA959699

• Gene Names: Rock2; Rock2m; Rock-II; ROKalpha; mKIAA0619; Rho-kinase; B230113H15Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Rho-associated protein kinase 2 (Rock2); Recombinant Mouse Rho-associated protein kinase 2 (Rock2); partial; Rock2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,444

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Rock2 recombinant protein

This protein is a serine
threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.

NCBI and Uniprot Product Information

• NCBI GI #: 134949013
• NCBI GeneID: 19878
• NCBI Accession #: NP_033098.2
• NCBI GenBank Nucleotide #: NM_009072.2
• UniProt Accession #: P70336; Q8BR64; Q8CBR0; A5XDA7
• Molecular Weight: 166,760 Da
• NCBI Official Full Name: rho-associated protein kinase 2
• NCBI Official Synonym Full Names: Rho-associated coiled-coil containing protein kinase 2
• NCBI Official Symbol: Rock2
• NCBI Official Synonym Symbols: Rock2m; Rock-II; ROKalpha; mKIAA0619; Rho-kinase; B230113H15Rik
• NCBI Protein Information: rho-associated protein kinase 2
• UniProt Protein Name: Rho-associated protein kinase 2
• Protein Family: Rho-associated protein kinase
• UniProt Gene Name: Rock2
• UniProt Synonym Gene Names: ROCK-II

Uniprot Description

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays a role in placental homeostasis during the perinatal period. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca2+ sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.