Human ring finger protein (C3H2C3 type) 6 ELISA Kit | RNF6 elisa kit

Human E3 ubiquitin-protein ligase RNF6, RNF6 ELISA Kit

Cat. Num. AAA9320730

• Reactivity: Human
• Synonyms: ring finger protein (C3H2C3 type) 6; Human E3 ubiquitin-protein ligase RNF6; RNF6 ELISA Kit; Human E3 ubiquitin-protein ligase RNF6 (RNF6) ELISA kit; DKFZp686P0776; OTTHUMP00000018154; RING-H2 protein RNF-6; ring finger protein 6; RNF6 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 5174653
• NCBI GeneID: 6049
• NCBI Accession #: NP_005968.1
• NCBI GenBank Nucleotide #: NM_005977.3
• UniProt Accession #: Q9Y252; Q5W0H0; Q9BZP5; Q9UF41; B4DDP0
• Molecular Weight: 78,091 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase RNF6
• NCBI Official Synonym Full Names: ring finger protein (C3H2C3 type) 6
• NCBI Official Symbol: RNF6
• NCBI Protein Information: E3 ubiquitin-protein ligase RNF6; RING-H2 protein RNF-6
• UniProt Protein Name: E3 ubiquitin-protein ligase RNF6
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: RNF6
• UniProt Synonym Gene Names: SPG2
• UniProt Entry Name: RNF6_HUMAN

NCBI Description

The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008]

Uniprot Description

RNF6: E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. Defects in RNF6 may be a cause of esophageal cancer (ESCR). A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. Belongs to the RNF12 family.

Protein type: Ligase; Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 13q12.2

Cellular Component: PML body; nuclear membrane; intracellular membrane-bound organelle; axon; cytoplasm; nucleus

Molecular Function: protein binding; androgen receptor binding; DNA binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: ubiquitin-dependent protein catabolic process; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of axon extension

Disease: Esophageal Cancer