Human ring finger protein 41 ELISA Kit | RNF41 elisa kit

Human E3 ubiquitin-protein ligase NRDP1, RNF41 ELISA Kit

Cat. Num. AAA9321985

• Gene Names: RNF41; FLRF; NRDP1; SBBI03
• Reactivity: Human
• Synonyms: ring finger protein 41; Human E3 ubiquitin-protein ligase NRDP1; RNF41 ELISA Kit; Human E3 ubiquitin-protein ligase NRDP1 (RNF41) ELISA kit; MGC45228; NRDP1; SBBI03; neuregulin receptor degradation protein-1; RNF41 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 338827618
• NCBI GeneID: 10193
• NCBI Accession #: NP_001229755.1
• NCBI GenBank Nucleotide #: NM_001242826.1
• UniProt Accession #: Q9H4P4; O75598; A6NFW0; B2RBT8
• Molecular Weight: 35,905 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase NRDP1 isoform 1
• NCBI Official Synonym Full Names: ring finger protein 41, E3 ubiquitin protein ligase
• NCBI Official Symbol: RNF41
• NCBI Official Synonym Symbols: FLRF; NRDP1; SBBI03
• NCBI Protein Information: E3 ubiquitin-protein ligase NRDP1; fetal liver ring finger; neuregulin receptor degradation protein-1
• UniProt Protein Name: E3 ubiquitin-protein ligase NRDP1
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: RNF41
• UniProt Synonym Gene Names: FLRF; NRDP1; SBBI03
• UniProt Entry Name: RNF41_HUMAN

NCBI Description

This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

Uniprot Description

RNF41: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 and Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL- 3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state.

Protein type: Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.19; EC 6.3.2.-; Ligase

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: cytosol

Molecular Function: protein binding; interleukin-3 receptor binding; protein tag; erythropoietin receptor binding; acid-amino acid ligase activity; zinc ion binding; Ral GTPase binding; ubiquitin-protein ligase activity

Biological Process: proteasomal protein catabolic process; negative regulation of cell proliferation; regulation of myeloid cell differentiation; protein autoubiquitination; protein polyubiquitination; regulation of lymphocyte differentiation; regulation of MAPKKK cascade; autophagy; positive regulation of transcription factor activity; regulation of protein kinase B signaling cascade; negative regulation of cell migration