Human ring finger protein 20 ELISA Kit | RNF20 elisa kit
Human E3 ubiquitin-protein ligase BRE1A, RNF20 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012]
Uniprot Description
RNF20: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6. Interacts with p53/TP53 and WAC. Interacts with PAF1; the interaction mediates the association of the PAF1 and RNF20/40 complexes which is a prerequsite for recruitment of UBE2A/B. Belongs to the BRE1 family.
Protein type: EC 6.3.2.-; EC 6.3.2.19; Ubiquitin conjugating system; Ligase; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 9q22
Cellular Component: nucleoplasm; nucleolus; nucleus; ubiquitin ligase complex
Molecular Function: protein binding; mRNA 3'-UTR binding; zinc ion binding; histone binding; p53 binding; ubiquitin protein ligase binding; transcription coactivator activity; ubiquitin-protein ligase activity; chromatin binding; ligase activity
Biological Process: ubiquitin-dependent protein catabolic process; histone monoubiquitination; positive regulation of histone methylation; protein polyubiquitination; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; histone H2B ubiquitination; regulation of mitotic cell cycle; negative regulation of cell migration
Research Articles on RNF20
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Product Notes
The Human RNF20 rnf20 (Catalog #AAA9330861) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9330861 ELISA Kit recognizes Human RNF20. It is sometimes possible for the material contained within the vial of "ring finger protein 20, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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