E3 ubiquitin-protein ligase RNF146-B (RNF146B) Recombinant Protein | RNF146B recombinant protein
Recombinant Bovine E3 ubiquitin-protein ligase RNF146-B (RNF146B)
Gene Names
RNF146; RNF146B
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
E3 ubiquitin-protein ligase RNF146-B (RNF146B); Recombinant Bovine E3 ubiquitin-protein ligase RNF146-B (RNF146B); RNF146B recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-347, full length protein
Sequence
MMAGCGEIDHSINMLPTNRKANESCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGNGEYAWYYEGRNGWWQYDERTSRELEDAFSKGKKSTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCDANTVNLARESSADGADSVPAQSGASVQSSSVRPLTSVDGQLTSPATPSPDAGTSLEDSFAHLQLGGDSIAERSHRGEGEEEHESPSSGRVPAPDTSIEETESDASSDSEDVSALVAQHSLTQQRLLVPNPSQTVSDRSVAAGGTVSVRSRRPDGQCTVTEV
Sequence Length
347
Species
Bovine
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
37,616 Da
NCBI Official Full Name
E3 ubiquitin-protein ligase RNF146-B
NCBI Official Symbol
RNF146
NCBI Official Synonym Symbols
RNF146B
NCBI Protein Information
E3 ubiquitin-protein ligase RNF146-B
UniProt Protein Name
E3 ubiquitin-protein ligase RNF146-B
Protein Family
UniProt Gene Name
RNF146B
Uniprot Description
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain and mediates their ubiquitination ().
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Product Notes
The RNF146B rnf146b (Catalog #AAA1475902) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-347, full length protein. The amino acid sequence is listed below: MMAGCGEIDH SINMLPTNRK ANESCSNTAP SLTVPECAIC LQTCVHPVSL PCKHVFCYLC VKGASWLGKR CALCRQEIPE DFLDKPTLLS PEELKAASRG NGEYAWYYEG RNGWWQYDER TSRELEDAFS KGKKSTEMLI AGFLYVADLE NMVQYRRNEH GRRRKIKRDI IDIPKKGVAG LRLDCDANTV NLARESSADG ADSVPAQSGA SVQSSSVRPL TSVDGQLTSP ATPSPDAGTS LEDSFAHLQL GGDSIAERSH RGEGEEEHES PSSGRVPAPD TSIEETESDA SSDSEDVSAL VAQHSLTQQR LLVPNPSQTV SDRSVAAGGT VSVRSRRPDG QCTVTEV. It is sometimes possible for the material contained within the vial of "E3 ubiquitin-protein ligase RNF146-B (RNF146B), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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