E3 ubiquitin-protein ligase RMA1 (RMA1) Recombinant Protein | RMA1 recombinant protein
Recombinant Arabidopsis thaliana E3 ubiquitin-protein ligase RMA1 (RMA1)
NCBI and Uniprot Product Information
NCBI Description
RMA1 encodes a novel 28 kDa protein with a RING finger motif and a C-terminal membrane-anchoring domain that is involved in the secretory pathway. Has E3 ubiquitin ligase activity.
Uniprot Description
Function: E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of aquaporin PIP2-1. Forms a ubiquitin ligase complex in cooperation with the E2 enzymes UCB8/UCB10. Ref.5 Ref.6 Ref.7
Pathway: Protein modification; protein ubiquitination.
Subcellular location: Endoplasmic reticulum membrane; Single-pass type IV membrane protein Ref.5 Ref.6 Ref.7.
Tissue specificity: Ubiquitous. Highly expressed in roots. Ref.1 Ref.6
Domain: The RING-type zinc finger domain is required for E3 ligase activity.The C-terminal transmembrane is dispensable for the ubiquitin ligase activity in vitro, but is critical for correct subcellular localization and substrate recognition in vivo.
Disruption phenotype: No visible phenotype and no effect on drought stress response, probably due to the redundancy with RMA2 and RMA3. Ref.7
Sequence similarities: Contains 1 RING-type zinc finger.
Research Articles on RMA1
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Product Notes
The RMA1 rma1 (Catalog #AAA1179787) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-249. The amino acid sequence is listed below: MALDQSFEDA ALLGELYGEG AFCFKSKKPE PITVSVPSDD TDDSNFDCNI CLDSVQEPVV TLCGHLFCWP CIHKWLDVQS FSTSDEYQRH RQCPVCKSKV SHSTLVPLYG RGRCTTQEEG KNSVPKRPVG PVYRLEMPNS PYASTDLRLS QRVHFNSPQE GYYPVSGVMS SNSLSYSAVL DPVMVMVGEM VATRLFGTRV MDRFAYPDTY NLAGTSGPRM RRRIMQADKS LGRIFFFFMC CVVLCLLLF. It is sometimes possible for the material contained within the vial of "E3 ubiquitin-protein ligase RMA1 (RMA1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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