Western Blot (WB)
(ADCYAP1 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the ADCYAP1 antibody detected the ADCYAP1 protein (arrow).)
Rabbit ADCYAP1 Polyclonal Antibody | anti-ADCYAP1 antibody
ADCYAP1 Antibody (C-term)
Western Blot (WB)
(ADCYAP1 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the ADCYAP1 antibody detected the ADCYAP1 protein (arrow).)
Western Blot (WB)
(ADCYAP1 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the ADCYAP1 antibody detected the ADCYAP1 protein (arrow).)
Immunohistochemistry (IHC)
(ADCYAP1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ADCYAP1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(ADCYAP1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ADCYAP1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunofluorescence (IF)
(Confocal immunofluorescent analysis of ADCYAP1 Antibody (C-term) with 293 cell followed by Alexa Fluor??488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).)
Immunofluorescence (IF)
(Confocal immunofluorescent analysis of ADCYAP1 Antibody (C-term) with 293 cell followed by Alexa Fluor??488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).)
Flow Cytometry (FC/FACS)
(ADCYAP1 Antibody (C-term) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(ADCYAP1 Antibody (C-term) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
1. Mediated by adenylate cyclase activating polypeptide 1
receptors, this polypeptide stimulates adenylate cyclase and
subsequently increases the cAMP level in target cells. Adenylate
cyclase activating polypeptide 1 is not only a hypophysiotropic
hormone, but also functions as a neurotransmitter and
neuromodulator. In addition, it plays a role in paracrine and
autocrine regulation of certain types of cells. This gene encodes
three different mature peptides, including two isotypes, a shorter
form and a longer form.
Ohkubo, S., et al. DNA Cell Biol. 11(1):21-30(1992)
Kimura, C., et al. Biochem. Biophys. Res. Commun. 166(1):81-89(1990)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
Uniprot Description
ADCYAP1: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Belongs to the glucagon family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 18p11
Cellular Component: extracellular space; extracellular region; terminal button
Molecular Function: neuropeptide hormone activity; peptide hormone receptor binding; receptor signaling protein activity; pituitary adenylate cyclase-activating peptide receptor binding; pituitary adenylate cyclase activating polypeptide activity; receptor binding
Biological Process: behavioral fear response; nerve growth factor receptor signaling pathway; negative regulation of potassium ion transport; female pregnancy; sensory perception of pain; positive regulation of vasodilation; positive regulation of synaptic transmission, glutamatergic; negative regulation of cell cycle; histamine secretion; cAMP-mediated signaling; elevation of cytosolic calcium ion concentration; regulation of protein localization; ovarian follicle development; cell-cell signaling; neuropeptide signaling pathway; positive regulation of cell proliferation; neurite development; adenylate cyclase activation; negative regulation of acute inflammatory response to antigenic stimulus; positive regulation of interleukin-6 production; positive regulation of growth hormone secretion; response to starvation; ATP metabolic process; regulation of postsynaptic membrane potential; response to ethanol; pituitary gland development; positive regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of acute inflammatory response to non-antigenic stimulus; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of G-protein coupled receptor protein signaling pathway
Research Articles on ADCYAP1
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Product Notes
The ADCYAP1 adcyap1 (Catalog #AAA9202944) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 148-176. The ADCYAP1 Antibody (C-term) reacts with Human (Predicted Reactivity: Mouse, Pig, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's ADCYAP1 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). WB~~1:1000. Researchers should empirically determine the suitability of the ADCYAP1 adcyap1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ADCYAP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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