RLBP1 recombinant protein

RLBP1, 1-317aa, Human, His-tag, Baculovirus

Cat. Num. AAA206416

• Gene Names: RLBP1; CRALBP
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: RLBP1; 1-317aa; Human; His-tag; Baculovirus; Retinaldehyde binding protein 1; CRALBP; Cellular retinaldehyde binding protein like; CRALBPL; FLJ37248; Retinaldehyde binding protein 1 like 1; RLBP1L1; RLBP1 recombinant protein

• Host: Baculovirus
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In phosphate buffered saline (pH 7.4) containing 20% glycerol.
• Concentration: 0.5 mg/ml (determined by Absorbance at 280nm) (varies by lot)
• Sequence: ADPMSEGVGT FRMVPEEEQE LRAQLEQLTT KDHGPVFGPC SQLPRHTLQK AKDELNEREE TREEAVRELQ EMVQAQAASG EELAVAVAER VQEKDSGFFL RFIRARKFNV GRAYELLRGY VNFRLQYPEL FDSLSPEAVR CTIEAGYPGV LSSRDKYGRV VMLFNIENWQ SQEITFDEIL QAYCFILEKL LENEETQING FCIIENFKGF TMQQAASLRT SDLRKMVDML QDSFPARFKA IHFIHQPWYF TTTYNVVKPF LKSKLLERVF VHGDDLSGFY QEIDENILPS DFGGTLPKYD GKAVAEQLFG PQAQAENTAF HHHHHH
• Sequence Length: 317

• Applicable Applications for RLBP1 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Endotoxin Level: < 1.0 EU per 1 microgram of protein (determined by LAL method)
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for RLBP1 recombinant protein

RLBP1, as known as retinaldehyde binding protein 1, is a soluble protein. It participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'. Recombinant human RLBP1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Categories/Family for RLBP1 recombinant protein

Neuroscience

References

Neutzner RV., et al. (2011) Ophthalmologe 108:1045-1049.; Intres R., et al. (1994) J. Biol. Chem. 269:25411-25418.;

NCBI and Uniprot Product Information

• NCBI GI #: 4506541
• NCBI GeneID: 6017
• NCBI Accession #: NP_000317
• NCBI GenBank Nucleotide #: NM_000326.4
• UniProt Accession #: P12271; B2R667
• Molecular Weight: 37.5kDa (326aa) 28-40kDa (SDS-PAGE under reducing conditions)
• NCBI Official Full Name: retinaldehyde-binding protein 1
• NCBI Official Synonym Full Names: retinaldehyde binding protein 1
• NCBI Official Symbol: RLBP1
• NCBI Official Synonym Symbols: CRALBP
• NCBI Protein Information: retinaldehyde-binding protein 1
• UniProt Protein Name: Retinaldehyde-binding protein 1
• Protein Family: Retinaldehyde-binding protein
• UniProt Gene Name: RLBP1
• UniProt Synonym Gene Names: CRALBP

NCBI Description

The protein encoded by this gene is a 36-kD water-soluble protein which carries 11-cis-retinaldehyde or 11-cis-retinal as physiologic ligands. It may be a functional component of the visual cycle. Mutations of this gene have been associated with severe rod-cone dystrophy, Bothnia dystrophy (nonsyndromic autosomal recessive retinitis pigmentosa) and retinitis punctata albescens. [provided by RefSeq, Jul 2008]

Uniprot Description

Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.