Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) Recombinant Protein | RIPK3 recombinant protein

Recombinant Human Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)

Cat. Num. AAA1442585

• Gene Names: RIPK3; RIP3
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Receptor-interacting serine/threonine-protein kinase 3 (RIPK3); Recombinant Human Receptor-interacting serine/threonine-protein kinase 3 (RIPK3); RIP-like protein kinase 3; Receptor-interacting protein 3; RIP-3; RIPK3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-518aa; Full Length
• Sequence: MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSSVPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLAPSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK

• Species: Homo sapiens (Human)
• Production Note: Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to [email protected] for more details.
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-Page

Related Product Information for RIPK3 recombinant protein

Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Product Categories/Family for RIPK3 recombinant protein

Cell Biology

References

"Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB." Yu P.W., Huang B.C.B., Shen M., Quast J., Chan E., Xu X., Nolan G.P., Payan D.G., Luo Y. Curr. Biol. 9:539-542(1999)

NCBI and Uniprot Product Information

• NCBI GI #: 40254844
• NCBI GeneID: 11035
• NCBI Accession #: NP_006862.2
• NCBI GenBank Nucleotide #: NM_006871.3
• UniProt Accession #: Q9Y572; Q5J795; Q5J796; Q6P5Y1; B4DJL9; C4AM87
• Molecular Weight: 58.9 kDa
• NCBI Official Full Name: receptor-interacting serine/threonine-protein kinase 3
• NCBI Official Synonym Full Names: receptor interacting serine/threonine kinase 3
• NCBI Official Symbol: RIPK3
• NCBI Official Synonym Symbols: RIP3
• NCBI Protein Information: receptor-interacting serine/threonine-protein kinase 3
• UniProt Protein Name: Receptor-interacting serine/threonine-protein kinase 3
• Protein Family: Receptor-interacting serine/threonine-protein kinase
• UniProt Gene Name: RIPK3
• UniProt Synonym Gene Names: RIP3; RIP-3
• UniProt Entry Name: RIPK3_HUMAN

NCBI Description

The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]

Uniprot Description

RIPK3: Promotes apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; TKL group; RIPK family

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: cytosol; mitochondrion; plasma membrane

Molecular Function: ATP binding; identical protein binding; NF-kappaB-inducing kinase activity; protein binding; protein complex binding; protein kinase activity; protein serine/threonine kinase activity; transcription coactivator activity

Biological Process: activation of NF-kappaB transcription factor; activation of protein kinase activity; I-kappaB kinase/NF-kappaB cascade; innate immune response; lymph node development; MyD88-independent toll-like receptor signaling pathway; positive regulation of interferon type I production; positive regulation of ligase activity; positive regulation of oxidoreductase activity; programmed cell death; protein amino acid autophosphorylation; protein heterooligomerization; protein homooligomerization; protein modification process; regulation of activated T cell proliferation; regulation of adaptive immune response; regulation of interferon-gamma production; regulation of T cell mediated cytotoxicity; signal transduction; spleen development; T cell differentiation in the thymus; T cell homeostasis; thymus development; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway