Rat ring finger protein 1 ELISA Kit | RING1 elisa kit
Rat E3 ubiquitin-protein ligase RING1, RING1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
maps within the major histocompatibility complex RT1 region [RGD, Feb 2006]
Uniprot Description
RING1: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity)
Protein type: EC 6.3.2.19; Ligase; EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system; Transcription factor
Cellular Component: nucleoplasm; nuclear body; sex chromatin; cytoplasm; nuclear speck; PcG protein complex; nucleus; ubiquitin ligase complex
Molecular Function: zinc ion binding; ubiquitin-protein ligase activity; chromatin binding; ligase activity
Biological Process: anterior/posterior pattern formation; camera-type eye morphogenesis; transcription, DNA-dependent; regulation of catalytic activity; histone ubiquitination; negative regulation of transcription, DNA-dependent
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Product Notes
The Rat RING1 ring1 (Catalog #AAA9337918) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9337918 ELISA Kit recognizes Rat RING1. It is sometimes possible for the material contained within the vial of "ring finger protein 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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