Rat Ras and Rab interactor 1 ELISA Kit | RIN1 elisa kit
Rat Ras and Rab interactor 1, RIN1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
may act as a regulator of Ras-mediated signal transduction [RGD, Feb 2006]
Uniprot Description
Rin1: Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-351. Expressed in all tissues examined with high levels in brain, placenta and pancreas. Belongs to the RIN (Ras interaction/interference) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs; GEFs, Rab
Cellular Component: cytoskeleton; cell soma; membrane; dendrite; cytoplasm; plasma membrane
Molecular Function: Ras GTPase binding; GTPase activator activity
Biological Process: negative regulation of synaptic plasticity; endocytosis; signal transduction; associative learning; memory; positive regulation of GTPase activity
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Product Notes
The Rat RIN1 rin1 (Catalog #AAA9340702) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9340702 ELISA Kit recognizes Rat RIN1. It is sometimes possible for the material contained within the vial of "Ras and Rab interactor 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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