Regulator of G-protein signaling 7 Recombinant Protein | RGS7 recombinant protein

Recombinant Human Regulator of G-protein signaling 7

Cat. Num. AAA9420616

• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Regulator of G-protein signaling 7; Recombinant Human Regulator of G-protein signaling 7; RGS7 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Full Length of isoform5, 1-487aa

• Tag Info: His-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for RGS7 recombinant protein

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving th into their inactive GDP-bound form. Activity on G (o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations.

NCBI and Uniprot Product Information

• NCBI GI #: 544346172
• NCBI GeneID: 6000
• NCBI Accession #: NP_001269702.1
• NCBI GenBank Nucleotide #: NM_001282773.2
• UniProt Accession #: P49802; Q5T3H4; Q8TD66; Q8TD67; Q8WW09; Q9UNU7; Q9Y6B9
• Molecular Weight: 60.81kD
• NCBI Official Full Name: regulator of G-protein signaling 7 isoform 2
• NCBI Official Synonym Full Names: regulator of G protein signaling 7
• NCBI Official Symbol: RGS7
• NCBI Protein Information: regulator of G-protein signaling 7
• UniProt Protein Name: Regulator of G-protein signaling 7
• Protein Family: Regulator of G-protein signaling
• UniProt Gene Name: RGS7
• UniProt Synonym Gene Names: RGS7

Uniprot Description

RGS7: inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations. Heterodimer with GNG5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity). Interacts with 14-3-3 protein Tau and SNAP25BP. Four alternatively spliced isoforms have been described.

Protein type: GAP; GAP, RGS

Chromosomal Location of Human Ortholog: 1q43|1q23.1

Cellular Component: cytosol; plasma membrane

Molecular Function: G-protein beta-subunit binding; GTPase activator activity

Biological Process: positive regulation of GTPase activity; protein folding