RGS5 recombinant protein

RGS5 Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8121832

• Gene Names: RGS5; MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129
• Purity: >90% as determined by SDS-PAGE
• Synonyms: RGS5; RGS5 Protein; Human; Recombinant (His Tag); Human RGS5/Regulator of G-protein signaling 5 Protein (His Tag); MST092 Protein; MST106 Protein; MST129 Protein; MSTP032 Protein; MSTP092 Protein; MSTP106 Protein; MSTP129 Protein; regulator of G-protein signaling 5; RGS5 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Lys181

• Species: Human
• Predicted N Terminal: His
• Tag: N-His
• Protein Construction: A DNA sequence encoding the human RGS5 (NP_003608.1)(Met1-Lys181) was expressed with a polyhistidine tag at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for RGS5 recombinant protein

Background: RGS5 is a member of the RGS superfamily and acts as a negative regulator of heterotrimeric G protein-mediated signalling through G protein-coupled receptors (GPCRs). The regulator of G-protein signaling (RGS) proteins have recently been identified as signal transduction molecules which have structural homology to SST2 of Saccharomyces cerevisiae and EGL-10 of Caenorhabditis elegans. The messenger RNA of hRGS5 was abundantly expressed in heart, lung, skeletal muscle, and small intestine, and at low levels in brain, placenta, liver, colon, and leukocytes.

Product Categories/Family for RGS5 recombinant protein

G Protein-coupled Receptors Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 4506519
• NCBI GeneID: 8490
• NCBI Accession #: NP_003608.1
• NCBI GenBank Nucleotide #: NM_003617.3
• UniProt Accession #: O15539; Q53XA9; Q599J0; Q7LCP5; Q9H3F2
• Molecular Weight: 20,946 Da
• NCBI Official Full Name: regulator of G-protein signaling 5 isoform 1
• NCBI Official Synonym Full Names: regulator of G-protein signaling 5
• NCBI Official Symbol: RGS5
• NCBI Official Synonym Symbols: MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129
• NCBI Protein Information: regulator of G-protein signaling 5; OTTHUMP00000032361; OTTHUMP00000232302
• UniProt Protein Name: Regulator of G-protein signaling 5
• Protein Family: Regulator of G-protein signaling
• UniProt Gene Name: RGS5
• UniProt Synonym Gene Names: RGS5
• UniProt Entry Name: RGS5_HUMAN

Uniprot Description

RGS5: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, RGS

Chromosomal Location of Human Ortholog: 1q23.1

Cellular Component: cytoplasm; plasma membrane

Molecular Function: GTPase activator activity

Biological Process: signal transduction; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity

Disease: Hypertension, Essential