Chicken Regulator of G Protein Signaling 4 ELISA Kit | RGS4 elisa kit

Chicken Regulator of G Protein Signaling 4 ELISA Kit

• Gene Names: RGS4; RGP4; SCZD9
• Reactivity: Chicken
• Synonyms: Regulator of G Protein Signaling 4; Chicken Regulator of G Protein Signaling 4 ELISA Kit; RGS4 elisa kit

• Reactivity: Chicken

• Assay Type: Sandwich
• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 5032039
• NCBI GeneID: 5999
• NCBI Accession #: NP_005604.1
• NCBI GenBank Nucleotide #: NM_005613.5
• UniProt Accession #: P49798; A7XA56; A7XA58; A7XA59; A7YVV7; B1APZ3
• Molecular Weight: 23,256 Da
• NCBI Official Full Name: regulator of G-protein signaling 4 isoform 2
• NCBI Official Synonym Full Names: regulator of G-protein signaling 4
• NCBI Official Symbol: RGS4
• NCBI Official Synonym Symbols: RGP4; SCZD9
• NCBI Protein Information: regulator of G-protein signaling 4; schizophrenia disorder 9
• UniProt Protein Name: Regulator of G-protein signaling 4
• Protein Family: Regulator of G-protein signaling
• UniProt Gene Name: RGS4
• UniProt Synonym Gene Names: RGP4; RGS4
• UniProt Entry Name: RGS4_HUMAN

NCBI Description

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

RGS4: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs, RGS; GAPs

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: protein complex; cytoplasm; plasma membrane; cytosol

Molecular Function: calmodulin binding; G-protein alpha-subunit binding; GTPase activator activity

Biological Process: regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity; inactivation of MAPK activity

Disease: Schizophrenia 9