Rat regulator of G-protein signaling 14 ELISA Kit | RGS14 elisa kit
Rat Regulator of G-protein signaling 14, RGS14 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
binds Galpha(i1)GDP and acts as a GTPase activator by maintaining G-protein subunit dissociation; regulates G-protein mediated signaling [RGD, Feb 2006]
Uniprot Description
RGS14: Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not G(o) alpha subunit GNAO1 and G(i) alpha subunit GNAI2. Confers GAP activity on G(o) alpha subunit GNAI0 and G(i) alpha subunits GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS1 and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Probably required for the nerve growth factor (NGF)-mediated neurite outgrowth. May be involved in visual memory processing capacity and hippocampal-based learning and memory. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs; GAPs, RGS
Cellular Component: spindle pole; centrosome; microtubule; PML body; dendrite; postsynaptic density; dendritic spine; nuclear body; postsynaptic membrane; cytoplasm; plasma membrane; spindle; cell junction; nucleus
Molecular Function: protein binding; receptor signaling complex scaffold activity; microtubule binding; GDP-dissociation inhibitor activity; receptor signaling protein activity; G-protein alpha-subunit binding; GTPase activating protein binding; protein kinase binding; GTPase activator activity
Biological Process: regulation of transcription in response to stress; zygote asymmetric cell division; negative regulation of MAP kinase activity; mitosis; positive regulation of neurogenesis; negative regulation of synaptic plasticity; nucleocytoplasmic transport; platelet-derived growth factor receptor signaling pathway; learning; spindle organization and biogenesis; chromosome segregation; long-term memory; cell division; visual learning; response to oxidative stress; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity
Research Articles on RGS14
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Product Notes
The Rat RGS14 rgs14 (Catalog #AAA9330927) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9330927 ELISA Kit recognizes Rat RGS14. It is sometimes possible for the material contained within the vial of "regulator of G-protein signaling 14, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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