RENBP recombinant protein

Recombinant Human RENBP protein

Cat. Num. AAA1562641

• Gene Names: RENBP; RBP; RNBP
• Purity: >90% as determined by SDS-PAGE
• Synonyms: RENBP; Recombinant Human RENBP protein; N-acylglucosamine 2-epimerase; AGE; GlcNAc 2-epimerase; N-acetyl-D-glucosamine 2-epimerase; Renin-binding protein; RnBP; RENBP recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human RENBP (Met11-Gln254) was fused with His tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for RENBP recombinant protein

Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.

Product Categories/Family for RENBP recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 213417820
• NCBI GeneID: 5973
• NCBI Accession #: NP_002901.2
• NCBI GenBank Nucleotide #: NM_002910.5
• UniProt Accession #: P51606; Q96BI6; B4DNZ3
• Molecular Weight: 29,270 Da
• NCBI Official Full Name: N-acylglucosamine 2-epimerase
• NCBI Official Synonym Full Names: renin binding protein
• NCBI Official Symbol: RENBP
• NCBI Official Synonym Symbols: RBP; RNBP
• NCBI Protein Information: N-acylglucosamine 2-epimerase
• UniProt Protein Name: N-acylglucosamine 2-epimerase
• Protein Family: N-acylglucosamine 2-epimerase
• UniProt Gene Name: RENBP
• UniProt Synonym Gene Names: AGE; RnBP

NCBI Description

The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq, Jul 2008]

Uniprot Description

Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.