RELT / TNFRSF19L recombinant protein
Recombinant Human RELT / TNFRSF19L Protein (His & Fc tag)
Gene Names
RELT; TRLT; TNFRSF19L
Purity
> 90 % as determined by SDS-PAGE
Synonyms
RELT / TNFRSF19L; Recombinant Human RELT / TNFRSF19L Protein (His & Fc tag); FLJ14993; TNFRSF19L; RELT / TNFRSF19L recombinant protein
Host
Human Cells
Purity/Purification
> 90 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
430
Application Notes
The recombinant human RELT/Fc is a disulfide-linked homodimer. The reduced monomer consists of 383 amino acids and has a predicted molecular mass of 42 kDa. As a result of glycosylation, the apparent molecular mass of rh RELT/Fc monomer migrates with an apparent molecular mass of 55-60 kDa in SDS-PAGE under reducing conditions.
Predicted N Terminal
Ser 26
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
Related Product Information for RELT / TNFRSF19L recombinant protein
Background: Receptor expressed in lymphoid tissues (RELT), also known as tumor necrosis factor receptor superfamily, member 19-like (TNFRSF19L), is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1. RELT/TNFRSF19L is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. RELT/TNFRSF19L is a type I transmembrane glycoprotein with a cysteine-rich extracellular domain, possessing significant homology to other members of the TNFR superfamily, especially TNFRSF19, DR3, OX40, and LTbeta receptor. RELT/TNFRSF19L is able to activate the NF-kappaB pathway and selectively binds tumor necrosis factor receptor-associated factor 1. RELT/TNFRSF19L is able to activate the NF-kappaB pathway and selectively binds tumor necrosis factor receptor-associated factor 1. Although the soluble form of RELT fusion protein does not inhibit the one-way mixed lymphocyte reaction, immobilized RELT/TNFRSF19L is capable of costimulating T-cell proliferation in the presence of CD3 signaling.
Description: A DNA sequence encoding the human RELT (NP_116260.2) extracellular domain (Met 1-Ala 160) with 127R/G & 129R/G mutation was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
Description: A DNA sequence encoding the human RELT (NP_116260.2) extracellular domain (Met 1-Ala 160) with 127R/G & 129R/G mutation was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
46,092 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 19L
NCBI Official Synonym Full Names
RELT tumor necrosis factor receptor
NCBI Official Symbol
RELT
NCBI Official Synonym Symbols
TRLT; TNFRSF19L
NCBI Protein Information
tumor necrosis factor receptor superfamily member 19L
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 19L
UniProt Gene Name
RELT
UniProt Synonym Gene Names
TNFRSF19L
NCBI Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Uniprot Description
RELT: Mediates activation of NF-kappa-B. May play a role in T- cell activation. Belongs to the RELT family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q13.4
Cellular Component: integral to plasma membrane
Molecular Function: tumor necrosis factor receptor activity
Biological Process: immune response; inflammatory response; multicellular organismal development; positive regulation of MAPKKK cascade; regulation of apoptosis; regulation of cell proliferation; response to lipopolysaccharide
Research Articles on RELT / TNFRSF19L
Similar Products
Product Notes
The RELT / TNFRSF19L relt (Catalog #AAA2546198) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant human RELT/Fc is a disulfide-linked homodimer. The reduced monomer consists of 383 amino acids and has a predicted molecular mass of 42 kDa. As a result of glycosylation, the apparent molecular mass of rh RELT/Fc monomer migrates with an apparent molecular mass of 55-60 kDa in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the RELT / TNFRSF19L relt for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RELT / TNFRSF19L, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
