Regenerating Islet Derived Protein 3 Alpha (REG3a) Recombinant Protein | REG3a recombinant protein

Recombinant Regenerating Islet Derived Protein 3 Alpha (REG3a)

Cat. Num. AAA2009488

• Gene Names: REG3A; HIP; PAP; PAP1; REG3; INGAP; PAP-H; PBCGF; HIP/PAP; REG-III
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: > 95%
• Synonyms: Regenerating Islet Derived Protein 3 Alpha (REG3a); Recombinant Regenerating Islet Derived Protein 3 Alpha (REG3a); REG3a recombinant protein

• Host: E Coli
• Purity/Purification: > 95%
• Form/Format: Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Sequence: The target protein is fused with N-terminal His-Tag, its sequence is listed below.; MGHHHHHHSGSEF-C PKGSKAYGSH CYALFLSPKS WTDADLACQK RPSGNLVSVL SGAEGSFVSS LVKSIGNSYS YVWIGLHDPT QGTEPNGEGW EWSSSDVMNY FAWERNPSTI SSPGHCASLS RSTAFLRWKD YNCN
• Sequence Length: 175

• Applicable Applications for REG3a recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Organism: Homo sapiens (Human)
• Expression System: Prokaryotic expression
• Residues: Cys40~Asn164 (Accession # Q06141) with N-terminal His-Tag
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Predicted isoelectric point: 7.1
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 4505605
• NCBI GeneID: 5068
• NCBI Accession #: NP_002571.1
• NCBI GenBank Nucleotide #: NM_002580.2
• UniProt Accession #: Q06141
• Molecular Weight: 14.6kDa
• NCBI Official Full Name: regenerating islet-derived protein 3-alpha
• NCBI Official Synonym Full Names: regenerating islet-derived 3 alpha
• NCBI Official Symbol: REG3A
• NCBI Official Synonym Symbols: HIP; PAP; PAP1; REG3; INGAP; PAP-H; PBCGF; HIP/PAP; REG-III
• NCBI Protein Information: regenerating islet-derived protein 3-alpha; REG-3-alpha; reg III-alpha; PAP homologous protein; human proislet peptide; pancreatitis-associated protein 1; proliferation-inducing protein 34; proliferation-inducing protein 42; hepatocarcinoma-intestine-pancreas; pancreatic beta cell growth factor; hepatointestinal pancreatic protein; regenerating islet-derived protein III-alpha
• UniProt Protein Name: Regenerating islet-derived protein 3-alpha
• Protein Family: Regenerating islet-derived protein
• UniProt Gene Name: REG3A
• UniProt Synonym Gene Names: HIP; PAP; PAP1; REG-3-alpha; HIP/PAP
• UniProt Entry Name: REG3A_HUMAN

NCBI Description

This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014]

Uniprot Description

REG3A: Might be a stress protein involved in the control of bacterial proliferation.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p12

Cellular Component: extracellular space; cytoplasm

Molecular Function: carbohydrate binding

Biological Process: heterophilic cell adhesion; cell proliferation; multicellular organismal development; negative regulation of keratinocyte differentiation; acute-phase response