Lithostathine 1 beta Recombinant Protein | REG1B recombinant protein
Lithostathine 1 beta, Recombinant, Human (Regenerating Protein 1 beta, REG1b)
Gene Names
REG1B; REGH; REGL; PSPS2; REGI-BETA
Purity
Highly Purified95% (SDS-PAGE); Two-step procedure using affinity Ni-NTA chromatography and size exclusion chromatography.
Synonyms
Lithostathine 1 beta; Recombinant; Human (Regenerating Protein 1 beta; REG1b); REG1B recombinant protein
Host
E Coli
Specificity
The amino acid sequence of the recombinant Human REG 1 beta is 100% homologous to the amino acid sequence of the Human REG 1 beta without signal sequence.
Purity/Purification
Highly Purified
95% (SDS-PAGE); Two-step procedure using affinity Ni-NTA chromatography and size exclusion chromatography.
95% (SDS-PAGE); Two-step procedure using affinity Ni-NTA chromatography and size exclusion chromatography.
Form/Format
Supplied as a lyophilized powder in 20mM Tris, pH 8.0.
Sequence
MKHHHHHHAS HM QESQTELP NPRISCPEGT NAYRSYCYYF NEDPETWVDA DLYCQNMNSG NLVSVLTQAE GAFVASLIKE SSTDDSNVWI GLHDPKKNRR WHWSSGSLVS YKSWDTGSPS SANAGYCASL TSCSGFKKWK DESCEKKFSF VCKFKN.
Application Notes
Western blotting, ELISA
Reconstitution
Add 0.2 ml of deionized H2O and let the lyophilized pellet dissolve completely.
Preparation and Storage
-20 degree C
Related Product Information for REG1B recombinant protein
Reg protein was shown to be stimulated during the regeneration of pancreatic islets. Since then, many Reg-related proteins have been identified in humans and other animals. In human, the four REG family genes, i.e., REG 1 alpha, REG 1 beta, REG-related sequence (RS) and HIP/PAP, have so far been isolated. These Reg-related proteins are classified into four subfamilies according to their amino-acid sequences, but they share a similar structure and physiological function. Reg protein is a growth factor for pancreatic beta cells and also suggest that the administration of Reg protein could be used as another therapeutic approach for diabetes mellitus. human REG cDNA which encoded a 166-amino acid protein with a 22-amino acid signal peptide. The amino acid sequence of human REG protein has 68% homology to that of rat Reg protein. Reg I was found to be expressed mainly in pancreatic beta and acinoductular cells as well as gastric fundic enterochromaffin-like (ECL) cells. Reg I production in ECL cells is stimulated by gastrin, as well as by the proinflammatory cytokine, cytokine-induced neutrophil chemoattractant (CINC)-2Beta. In patients with chronic hypergastrinemia, Reg production is stimulated, with the increased proliferation of gastric mucosal cells. Patients with Helicobacter pylori infection also showed increased Reg production in the gastric mucosa, partly via increased plasma gastrin concentration and partly via increased proinflammatory cytokine production. The serum concentration of the reg-protein was significantly higher in patients with various pancreatic diseases than in normal controls, and was also significantly higher in patients with acute pancreatitis or chronic relapsing pancreatitis than in patients with chronic pancreatitis. Furthermore, the serum PSP/reg-protein concentration was also significantly increased in liver cirrhosis, choledocholithiasis, and various cancers of the digestive system.
Recombinant Human REG 1 beta manufactured with N-terminal fusion of HisTag. The Human REG 1 beta His-Tagged Fusion Protein, produced in E. coli, is 17.8kD protein containing 144 amino acid residues of the Human REG 1 beta and 12 additional amino acid residues - HisTag.
Recombinant Human REG 1 beta manufactured with N-terminal fusion of HisTag. The Human REG 1 beta His-Tagged Fusion Protein, produced in E. coli, is 17.8kD protein containing 144 amino acid residues of the Human REG 1 beta and 12 additional amino acid residues - HisTag.
Product Categories/Family for REG1B recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
17.8kD
NCBI Official Full Name
lithostathine-1-beta
NCBI Official Synonym Full Names
regenerating islet-derived 1 beta
NCBI Official Symbol
REG1B
NCBI Official Synonym Symbols
REGH; REGL; PSPS2; REGI-BETA
NCBI Protein Information
lithostathine-1-beta; PSP-2; REG-1-beta; lithostathine 1 beta; pancreatic stone protein 2; regenerating protein I beta; secretory pancreatic stone protein 2; regenerating islet-derived protein 1-beta; regenerating islet-derived 1 beta (pancreatic stone protein, pancreatic thread protein)
UniProt Protein Name
Lithostathine-1-beta
Protein Family
UniProt Gene Name
REG1B
UniProt Synonym Gene Names
PSPS2; REGL; PSP-2; REG-1-beta
UniProt Entry Name
REG1B_HUMAN
NCBI Description
This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein secreted by the exocrine pancreas that is highly similar to the REG1A protein. The related REG1A protein is associated with islet cell regeneration and diabetogenesis, and may be involved in pancreatic lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]
Uniprot Description
REG1B: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2p12
Molecular Function: carbohydrate binding
Biological Process: cell proliferation
Research Articles on REG1B
Similar Products
Product Notes
The REG1B reg1b (Catalog #AAA638030) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. Western blotting, ELISA. Researchers should empirically determine the suitability of the REG1B reg1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MKHHHHHHAS HM QESQTELP NPRISCPEGT NAYRSYCYYF NEDPETWVDA DLYCQNMNSG NLVSVLTQAE GAFVASLIKE SSTDDSNVWI GLHDPKKNRR WHWSSGSLVS YKSWDTGSPS SANAGYCASL TSCSGFKKWK DESCEKKFSF VCKFKN. It is sometimes possible for the material contained within the vial of "Lithostathine 1 beta, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
