REG1A/PSPS recombinant protein

Recombinant Human REG1A/PSPS Protein (C-His)

Cat. Num. AAA2557151

• Gene Names: REG1A; P19; PSP; PTP; REG; ICRF; PSPS; PSPS1
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: REG1A/PSPS; Recombinant Human REG1A/PSPS Protein (C-His); Lithostathine-1-Alpha; Islet Cells Regeneration Factor; ICRF; Islet of Langerhans Regenerating Protein; REG; Pancreatic Stone Protein; PSP; Pancreatic Thread Protein; PTP; Regenerating Islet-Derived Protein 1-Alpha; REG-1-Alpha; Regenerating Protein I Alpha; REG1A; PSPS; PSPS1; REG1A/PSPS recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
• Sequence: Gln23-Asn166
• Sequence Length: 166

• Species: Human
• Endotoxin: < 1.0 EU per mug as determined by the LAL method.
• Fusion Tag: C-His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for REG1A/PSPS recombinant protein

Protein Construction: Recombinant Human Regenerating Islet-Derived Protein 1-alpha is produced by our mammalian expression system and the target gene encoding Gln23-Asn166 is expressed with a 6His tag at the C-terminus.

Background: Regenerating Islet-Derived Protein 1-alpha (REG1A) belongs to the Reg family of secreted proteins with a C-type lectic domain. REG1A is highly expressed levels in fetal and infant brains, much lower in adult brains. REG1A promotes the maintenance and growth of pancreatic islet cells and intestinal villi. In addition to, REG1A Might act as an inhibitor of spontaneous calcium carbonate precipitation and be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.

NCBI and Uniprot Product Information

• NCBI GI #: 131433
• NCBI GeneID: 5967
• UniProt Accession #: P05451
• Molecular Weight: Molecular Mass: 17.31kDa; Actual Protein Molecular Mass: 18kDa
• NCBI Official Full Name: Lithostathine-1-alpha
• NCBI Official Synonym Full Names: regenerating family member 1 alpha
• NCBI Official Symbol: REG1A
• NCBI Official Synonym Symbols: P19; PSP; PTP; REG; ICRF; PSPS; PSPS1
• NCBI Protein Information: lithostathine-1-alpha
• UniProt Protein Name: Lithostathine-1-alpha
• UniProt Gene Name: REG1A
• UniProt Synonym Gene Names: PSPS; PSPS1; REG; ICRF; REG; PSP; PTP; REG-1-alpha
• UniProt Entry Name: REG1A_HUMAN

NCBI Description

This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]

Uniprot Description

REG1A: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 2p12

Molecular Function: growth factor activity; carbohydrate binding

Biological Process: positive regulation of cell proliferation