Testing Data
Recombinant Human Thyroid Peroxidase (TPO) Recombinant Protein
Recombinant Human Thyroid Peroxidase (TPO)
Purity
Greater than 95% as determined by SDS-PAGE. Identity confirmed by MALDI mass spectrometry.
Synonyms
Recombinant Human Thyroid Peroxidase (TPO); Recombinant Human Thyroid Peroxidase (TPO) recombinant protein
Host
Insect Cell
Specificity
Recombinant Human Thyroid Peroxidase (TPO)
Purity/Purification
Greater than 95% as determined by SDS-PAGE. Identity confirmed by MALDI mass spectrometry.
Form/Format
Lyophilized from 20mM Tris-HCl, pH 8.0, 250mM NaCl, 0.1mM KI, 5% D-mannitol. Reconstitute with sterile deionized H2O.
Preparation and Storage
Store at 20 degree C in lyophilized form. After reconstitution, store at -70 degree C. Avoid repeated freezing and thawing.
Testing Data
Testing Data
Related Product Information for Recombinant Human Thyroid Peroxidase (TPO) recombinant protein
Thyroid peroxidase (TPO) is an integral apical membrane glycoprotein of thyroid follicular cells and plays a key role in thyroid hormone biosynthesis. It is a homodimer comprised of two identical subunits of approx. 100kDa. TPO is one of the main autoantigenic targets in autoimmune thyroid disease of humans. Anti-TPO autoantibodies are present in 90% of cases of Hashimoto's thyroiditis and 75% of cases of Graves' disease.
Recombinant human TPO produced in insect cells corresponds to aa 19-846 (calculated molecular weight approx. 92kDa) of the soluble extracellular domain of human TPO. It does not contain any tags. It is purified by specific monoclonal antibody-based affinityand ion exchange chromato-graphic methods. In SDS-PAGE, two bands in the region of 100-110kDa are observed due to differential glycosyl- ation of the protein. Immunoreactivity of rhuTPO is confirmed by ELISA with patient serum samples containing anti-TPO autoantibodies.
Recombinant human TPO produced in insect cells corresponds to aa 19-846 (calculated molecular weight approx. 92kDa) of the soluble extracellular domain of human TPO. It does not contain any tags. It is purified by specific monoclonal antibody-based affinityand ion exchange chromato-graphic methods. In SDS-PAGE, two bands in the region of 100-110kDa are observed due to differential glycosyl- ation of the protein. Immunoreactivity of rhuTPO is confirmed by ELISA with patient serum samples containing anti-TPO autoantibodies.
Similar Products
Product Notes
The Recombinant Human Thyroid Peroxidase (TPO) (Catalog #AAA197032) is a Recombinant Protein produced from Insect Cell and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Recombinant Human Thyroid Peroxidase (TPO), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
