Rat 11-cis retinol dehydrogenase ELISA Kit | RDH5 elisa kit
Rat 11-cis retinol dehydrogenase (RDH5) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an enzyme belonging to the short-chain dehydrogenases/reductases (SDR) family. This retinol dehydrogenase functions to catalyze the final step in the biosynthesis of 11-cis retinaldehyde, which is the universal chromophore of visual pigments. Mutations in this gene cause autosomal recessive fundus albipunctatus, a rare form of night blindness that is characterized by a delay in the regeneration of cone and rod photopigments. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S1 (biogenesis of lysosomal organelles complex-1, subunit 1) gene. [provided by RefSeq, Dec 2010]
Uniprot Description
RDH5: Stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. Also able to oxidize 9-cis-retinol and 13-cis-retinol, but not all- trans-retinol. Active in the presence of NAD as cofactor but not in the presence of NADP. Defects in RDH5 are a cause of retinitis punctata albescens (RPA); also known as fundus albipunctatus (FA). RPA is a rare form of stationary night blindness characterized by a delay in the regeneration of cone and rod photopigments. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein type: Endoplasmic reticulum; Oxidoreductase; EC 1.1.1.315; Cofactor and Vitamin Metabolism - retinol
Chromosomal Location of Human Ortholog: 12q13-q14
Cellular Component: endoplasmic reticulum lumen; endoplasmic reticulum membrane
Molecular Function: retinol dehydrogenase activity
Biological Process: phototransduction, visible light; retinoid metabolic process; retinol metabolic process; visual perception
Disease: Fundus Albipunctatus
Research Articles on RDH5
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Product Notes
The Rat RDH5 rdh5 (Catalog #AAA2603881) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2603881 ELISA Kit recognizes Rat RDH5. It is sometimes possible for the material contained within the vial of "11-cis retinol dehydrogenase, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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