RCVRN recombinant protein

Recombinant Human RCVRN protein

Cat. Num. AAA1562152

• Gene Names: RCVRN; RCV1
• Purity: >90% as determined by SDS-PAGE
• Synonyms: RCVRN; Recombinant Human RCVRN protein; Recoverin; Cancer-associated retinopathy protein; Protein CAR; RCVRN recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human RCVRN (Gly2-Ala200) was fused with His tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for RCVRN recombinant protein

Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells. Modulates light sensitivity of cone photoreceptor in dark and dim conditions. In response to high Ca2+ levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin. Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells. Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light.

Product Categories/Family for RCVRN recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 4506459
• NCBI GeneID: 5957
• NCBI Accession #: NP_002894.1
• NCBI GenBank Nucleotide #: NM_002903.2
• UniProt Accession #: P35243
• Molecular Weight: 23,130 Da
• NCBI Official Full Name: recoverin
• NCBI Official Synonym Full Names: recoverin
• NCBI Official Symbol: RCVRN
• NCBI Official Synonym Symbols: RCV1
• NCBI Protein Information: recoverin; cancer associated retinopathy antigen; cancer-associated retinopathy protein
• UniProt Protein Name: Recoverin
• Protein Family: Recoverin
• UniProt Gene Name: RCVRN
• UniProt Synonym Gene Names: RCV1; Protein CAR
• UniProt Entry Name: RECO_HUMAN

NCBI Description

This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy. [provided by RefSeq, Jul 2008]

Uniprot Description

RCV1: Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse. Belongs to the recoverin family.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: dendrite

Molecular Function: calcium sensitive guanylate cyclase activator activity; calcium ion binding

Biological Process: rhodopsin mediated signaling; phototransduction, visible light; regulation of rhodopsin mediated signaling; visual perception; positive regulation of guanylate cyclase activity; regulation of calcium ion transport; signal transduction