Reticulocalbin-3 Recombinant Protein | RCN3 recombinant protein

Recombinant Human Reticulocalbin-3 Protein

Cat. Num. AAA2556598

• Gene Names: RCN3; RLP49
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Reticulocalbin-3; Recombinant Human Reticulocalbin-3 Protein; EF-Hand Calcium-Binding Protein RLP49; RCN3; RCN3 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Supplied as a 0.2 mum filtered solution of 20mM TrisHCl, 150mM NaCl, 1mM DTT, 10% Glycerol, pH 7.4.
• Sequence Length: 328

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fragment: Lys21-Leu328
• Fusion Tag: C-6His
• Preparation and Storage: Store at < -20 degree C, stable for 6 months after receipt.; Please minimize freeze-thaw cycles.

SDS-Page

Related Product Information for RCN3 recombinant protein

Protein Construction: Recombinant Human Reticulocalbin-3 is produced by our Mammalian expression system and the target gene encoding Lys21-Leu328 is expressed with a 6His tag at the C-terminus.

Background: Reticulocalbin-3 is a member of the CREC family that is involved in the secretory pathway. Members of the CREC family consist of a number of multiple EF-hand domains. Reticulocalbin-3 localizes to the endoplasmic reticulum lumen. The bioinformaticanalysis of Reticulocalbin-3 reveal that it is a putative Ca2+-binding protein. In addition, it has been shown that autoactivation and secretion of PACE4 was increased upon co-expression with Reticulocalbin-3. The proPACE4-RCN-3 complex is plays an important role in the biosynthesis of PACE4.

NCBI and Uniprot Product Information

• NCBI GI #: 28626510
• NCBI GeneID: 57333
• NCBI Accession #: NP_065701.2
• NCBI GenBank Nucleotide #: NM_020650.3
• UniProt Accession #: Q96D15; Q9HBZ8
• Molecular Weight: Molecular Mass: 36.2kDa; Actual Protein Molecular Mass: 43kDa
• NCBI Official Full Name: reticulocalbin-3
• NCBI Official Synonym Full Names: reticulocalbin 3
• NCBI Official Symbol: RCN3
• NCBI Official Synonym Symbols: RLP49
• NCBI Protein Information: reticulocalbin-3
• UniProt Protein Name: Reticulocalbin-3
• Protein Family: Reticulocalbin
• UniProt Gene Name: RCN3

Uniprot Description

Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:16433634, PubMed:28939891). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (PubMed:28939891). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (PubMed:16433634).