Mouse RNA binding motif protein 4 ELISA Kit | RBM4 elisa kit

Mouse RNA-binding protein 4, RBM4 ELISA Kit

Cat. Num. AAA9326271

• Gene Names: Rbm4; lark; Lark1; Mlark; Rbm4a; 4921506I22Rik
• Reactivity: Mouse
• Synonyms: RNA binding motif protein 4; Mouse RNA-binding protein 4; RBM4 ELISA Kit; Mouse RNA-binding protein 4 (RBM4) ELISA kit; DKFZp547K0918; LARK; MGC75138; RBM4A; ZCCHC21; ZCRB3A; OTTHUMP00000205225; OTTHUMP00000205226; transcriptional coactivator CoAZ; zinc finger CCHC-type and RNA binding motif 3A; RBM4 elisa kit

• Reactivity: Mouse

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 588282738
• NCBI GeneID: 19653
• NCBI Accession #: NP_001277051.1
• NCBI GenBank Nucleotide #: NM_001290122.1
• UniProt Accession #: Q8C7Q4; O08752; Q8BN66
• Molecular Weight: 40,046 Da
• NCBI Official Full Name: RNA-binding protein 4 isoform a
• NCBI Official Synonym Full Names: RNA binding motif protein 4
• NCBI Official Symbol: Rbm4
• NCBI Official Synonym Symbols: lark; Lark1; Mlark; Rbm4a; 4921506I22Rik
• NCBI Protein Information: RNA-binding protein 4; lark homolog; RNA-binding motif protein 4a
• UniProt Protein Name: RNA-binding protein 4
• Protein Family: RNA-binding protein
• UniProt Gene Name: Rbm4
• UniProt Synonym Gene Names: Rbm4a; mLark
• UniProt Entry Name: RBM4_MOUSE

Uniprot Description

RBM4: RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of EIF2C2- containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA splicing; Nuclear receptor co-regulator; RNA-binding; Nucleolus

Cellular Component: nucleoplasm; cell; stress granule; cytoplasm; nucleolus; nuclear speck; nucleus

Molecular Function: mRNA binding; miRNA binding; mRNA 3'-UTR binding; RNA binding

Biological Process: negative regulation of translational initiation; regulation of insulin receptor signaling pathway; positive regulation of translation; response to arsenic; stress-activated MAPK cascade; miRNA-mediated gene silencing, negative regulation of translation; glucose homeostasis; negative regulation of translation in response to stress; regulation of gene expression; regulation of nucleocytoplasmic transport; negative regulation of translation; pancreas development; positive regulation of muscle cell differentiation; circadian regulation of gene expression; regulation of alternative nuclear mRNA splicing, via spliceosome