Testing Data
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Rabbit RBM4 Polyclonal Antibody | anti-RBM4 antibody
RBM4 (RNA-binding Motif Protein 4, LARK, RBM4A, ZCRB3A, ZCCHC21) (AP)
WB: 1:500-1:2000
IP: 1:20-1:50
Applications are based on unconjugated antibody.
Testing Data
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Testing Data
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NCBI and Uniprot Product Information
Uniprot Description
RBM4: RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of EIF2C2- containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA-binding; Nucleolus; RNA splicing; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: nucleoplasm; stress granule; cytoplasm; nucleolus; nuclear speck; nucleus
Molecular Function: mRNA binding; protein binding; miRNA binding; mRNA 3'-UTR binding; zinc ion binding; RNA binding; nucleotide binding
Biological Process: negative regulation of translational initiation; RNA splicing; response to arsenic; stress-activated MAPK cascade; miRNA-mediated gene silencing, negative regulation of translation; entrainment of circadian clock by photoperiod; RNA processing; negative regulation of translation in response to stress; regulation of nucleocytoplasmic transport; negative regulation of translation; positive regulation of muscle cell differentiation; cell differentiation; mRNA processing; regulation of alternative nuclear mRNA splicing, via spliceosome
Research Articles on RBM4
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Product Notes
The RBM4 rbm4 (Catalog #AAA6435175) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RBM4 (RNA-binding Motif Protein 4, LARK, RBM4A, ZCRB3A, ZCCHC21) (AP) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's RBM4 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB), Immunoprecipitation (IP). IHC: 1:50-1:200 WB: 1:500-1:2000 IP: 1:20-1:50 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the RBM4 rbm4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RBM4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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