Human RNA binding motif protein 15 ELISA Kit | RBM15 elisa kit

Human Putative RNA-binding protein 15, RBM15 ELISA Kit

Cat. Num. AAA9316242

• Gene Names: RBM15; OTT; OTT1; SPEN
• Reactivity: Human
• Synonyms: RNA binding motif protein 15; Human Putative RNA-binding protein 15; RBM15 ELISA Kit; Human Putative RNA-binding protein 15 (RBM15) ELISA kit; FLJ12479; FLJ21943; MGC119584; OTT; OTT1; SPEN; one twenty two protein; one twenty-two; RBM15 elisa kit

• Reactivity: Human

• Assay Type: Quantitative Sandwich
• Detection Range: 0.625ng/ml-20ng/ml
• Sensitivity: 0.1ng/ml
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for RBM15 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or test applications! This kit is intended to be used for determine the level of RBM15 (hereafter termed "analyte") in undiluted original Human serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 319996623
• NCBI GeneID: 64783
• NCBI Accession #: NP_001188474.1
• NCBI GenBank Nucleotide #: NM_001201545.1
• UniProt Accession #: Q96T37; Q3ZB86; Q4V760; Q5D058; Q5T613; Q86VW9; Q96PE4; Q96SC5; Q96SC6; Q96SC9; Q96SD0; A1A693
• Molecular Weight: 107,189 Da
• NCBI Official Full Name: putative RNA-binding protein 15 isoform 2
• NCBI Official Synonym Full Names: RNA binding motif protein 15
• NCBI Official Symbol: RBM15
• NCBI Official Synonym Symbols: OTT; OTT1; SPEN
• NCBI Protein Information: putative RNA-binding protein 15; one twenty-two; one twenty two protein; one-twenty two protein 1; RNA-binding motif protein 15
• UniProt Protein Name: Putative RNA-binding protein 15
• Protein Family: Putative RNA-binding protein
• UniProt Gene Name: RBM15
• UniProt Synonym Gene Names: OTT; OTT1
• UniProt Entry Name: RBM15_HUMAN

NCBI Description

Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]

Uniprot Description

RBM15: May be implicated in HOX gene regulation. A chromosomal aberration involving RBM15 may be a cause of acute megakaryoblastic leukemia. Translocation t(1;22)(p13;q13) with MKL1. Although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene and is the candidate oncogene. Belongs to the RRM Spen family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; RNA-binding; Spliceosome

Chromosomal Location of Human Ortholog: 1p13

Cellular Component: nucleoplasm; nuclear membrane

Molecular Function: protein binding; nucleotide binding

Biological Process: patterning of blood vessels; spleen development; negative regulation of myeloid cell differentiation; viral reproduction; negative regulation of transcription, DNA-dependent; activation of Notch receptor target transcription factor