BVR protein
BVR Protein
Reactivity
Rat
Applications
Western Blot, SDS-Page
Purity
Ion-exchange Purified
Synonyms
BVR; BVR Protein; Biliverdin Reductase Protein; Biliverdin IX alpha reductase Protein; Biliverdin reductase A Protein; Biliverdin-IX alpha-reductase Protein; BLVR A Protein; BLVR Protein; Blvra Protein; BVR A Protein; BVRA Protein; Zinc metalloProtein; zinc-metalloprotein Protein; BVR protein
Reactivity
Rat
Purity/Purification
Ion-exchange Purified
Concentration
0.82 mg/ml (varies by lot)
Sequence
MDAEPKRKFG VVVVGVGRAG SVRLRDLKDP RSAAFLNLIG FVSRRELGSL DEVRQISLED ALRSQEIDVA YICSESSSHE DYIRQFLQAG KHVLVEYPMT LSFAAAQELW ELAAQKGRVL HEEHVELLME EFEFLRREVL GKELLKGSLR FTASPLEEER FGFPAFSGIS RLTWLVSLFG ELSLISATLE ERKEDQYMKM TVQLETQNKG LLSWIEEKGP GLKRNRYVNF QFTSGSLEEV PSVGVNKNIF LKDQDIFVQK LLDQVSAEDL AAEKKRIMHC LGLASDIQKL CHQKK
Sequence Length
295
Applicable Applications for BVR protein
Western Blot (WB), SDS-PAGE
Target
BVR
Storage Buffer
10mM Tris pH7.5, 0.1mM EDTA, 0.2mM DTT, 20% glycerol
Conjugate
No tag
Cellular Localization
Cytoplasm
Expression System
Native
Protein Length
Full Length
Preparation and Storage
Store at -80 degree C
Related Product Information for BVR protein
Description: Rat Natural BVR Full Length Protein
Scientific Background: Biliverdin Reductase (BVR) is a cytoplasmic enzyme that catalyzes the conversion of biliverdin to bilirubin by converting a double bond between the second and third pyrrole ring into a single bond (1). It is ubiqutiously expressed in all tissues- it occurs in cells and brain regiuons that already display HO-1 and HO-2, but also in regions and cell types with potential to induce stress proteins. It is unique among all enzymes in having two pH optima, using a different cofactor at each pH range, NADH at pH7.0 and NADPH at pH8.7 (2). It is not inactivated by heat shock, and have shown to abate inflammation, oxidative stress and apoptosis (3).
Scientific Background: Biliverdin Reductase (BVR) is a cytoplasmic enzyme that catalyzes the conversion of biliverdin to bilirubin by converting a double bond between the second and third pyrrole ring into a single bond (1). It is ubiqutiously expressed in all tissues- it occurs in cells and brain regiuons that already display HO-1 and HO-2, but also in regions and cell types with potential to induce stress proteins. It is unique among all enzymes in having two pH optima, using a different cofactor at each pH range, NADH at pH7.0 and NADPH at pH8.7 (2). It is not inactivated by heat shock, and have shown to abate inflammation, oxidative stress and apoptosis (3).
Product Categories/Family for BVR protein
References
1. Singleton J.W., Laster L. (1965). J Biol Chem. 240: 4780-4789. 2. Kutty R.K., Maines M.D. (1981) J Biol Chem. 256: 3956-3962. 3. Mishra M., Ndisand J.F. (2014) Curr Pharm Des. 20(9): 1370-1391.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
33,566 Da
NCBI Official Full Name
biliverdin reductase A
NCBI Official Synonym Full Names
biliverdin reductase A
NCBI Official Symbol
Blvra
NCBI Protein Information
biliverdin reductase A
UniProt Protein Name
Biliverdin reductase A
UniProt Gene Name
Blvra
UniProt Synonym Gene Names
Blvr; BVR A
UniProt Entry Name
BIEA_RAT
NCBI Description
catalyzes the conversion of biliverdin to bilirubin in heme degradation [RGD, Feb 2006]
Uniprot Description
BVR: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Monomer. Liver. Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.
Protein type: Oxidoreductase; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.3.1.24; ATYPICAL group; BLVRA family
Molecular Function: biliverdin reductase activity
Research Articles on BVR
Similar Products
Product Notes
The BVR blvra (Catalog #AAA807884) is a Protein and is intended for research purposes only. The product is available for immediate purchase. The BVR Protein reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's BVR can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), SDS-PAGE. Researchers should empirically determine the suitability of the BVR blvra for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MDAEPKRKFG VVVVGVGRAG SVRLRDLKDP RSAAFLNLIG FVSRRELGSL DEVRQISLED ALRSQEIDVA YICSESSSHE DYIRQFLQAG KHVLVEYPMT LSFAAAQELW ELAAQKGRVL HEEHVELLME EFEFLRREVL GKELLKGSLR FTASPLEEER FGFPAFSGIS RLTWLVSLFG ELSLISATLE ERKEDQYMKM TVQLETQNKG LLSWIEEKGP GLKRNRYVNF QFTSGSLEEV PSVGVNKNIF LKDQDIFVQK LLDQVSAEDL AAEKKRIMHC LGLASDIQKL CHQKK. It is sometimes possible for the material contained within the vial of "BVR, Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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