Dopamine Transporter, Rat Peptide | Dbh peptide
Dopamine Transporter, Rat (DAT) Control Peptide
Highly purified
Highly purified
Dilution: ELISA: Coat plates at 1ug/ml.
Optimal dilution to be determined by researcher.
Dopamine transporter (DAT) is plasma membrane transporter for the termination of dopaminergic neurotransmission by its high affinity Na+ and Cl-reuptake of dopamine into presynaptic terminals. This protein is the target of psychomotor stimulants such as amphetamines or cocaine. DAT (human 620 aa; rat/mouse 619 aa glycoprotein) is predicted to contain 12 transmembrane domains with N and C-termini in the cytoplasm.
NCBI and Uniprot Product Information
NCBI Description
oxidoreductase that catalyzes the conversion of 3,4 dihydroxyphenethylamine, ascorbate, and O(2) to noradrenaline, dehydroascorbate, and H(2) in norephinephrine biosynthesis [RGD, Feb 2006]
Uniprot Description
Function: Conversion of dopamine to noradrenaline.
Catalytic activity: 3,4-dihydroxyphenethylamine + ascorbate + O2 = noradrenaline + dehydroascorbate + H2O.
Cofactor: Binds 1 PQQ per subunit
By similarity.Binds 2 copper ions per subunit
By similarity.
Pathway: Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1.
Subunit structure: Homotetramer composed of two non-covalently bound disulfide-linked dimers
By similarity.
Subcellular location: Soluble dopamine beta-hydroxylase: Cytoplasmic vesicle › secretory vesicle lumen
By similarity. Cytoplasmic vesicle › secretory vesicle › chromaffin granule lumen
By similarity Ref.2. Cytoplasmic vesicle › secretory vesicle membrane; Single-pass type II membrane protein
By similarity. Cytoplasmic vesicle › secretory vesicle › chromaffin granule membrane; Single-pass type II membrane protein
By similarity Ref.2.
Tissue specificity: Chromaffin granules of the adrenal medulla and synaptic vesicles of the sympathetic nervous system.
Sequence similarities: Belongs to the copper type II ascorbate-dependent monooxygenase family.Contains 1 DOMON domain.
Research Articles on Dbh
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Product Notes
The Dbh dbh (Catalog #AAA659439) is a Peptide produced from Rat and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Dopamine Transporter, Rat can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Antibody Blocking. Not suitable for Western Blot. Dilution: ELISA: Coat plates at 1ug/ml. Optimal dilution to be determined by researcher. Researchers should empirically determine the suitability of the Dbh dbh for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Dopamine Transporter, Rat, Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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