Rat Sonic Hedgehog N-Terminus (SHHN) ELISA Kit | SHHN elisa kit
Rat Sonic Hedgehog N-Terminus (SHHN) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008]
Uniprot Description
SHH: Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Interacts with HHATL/GUP1 which negatively regulates HHAT-mediated palmitoylation of the SHH N-terminus. N-product is active as a multimer. Expressed in fetal intestine, liver, lung, and kidney. Not expressed in adult tissues. Belongs to the hedgehog family.
Protein type: Cell cycle regulation; Cell development/differentiation; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 7q36.3
Cellular Component: cell surface; cytosol; endoplasmic reticulum lumen; extracellular region; extracellular space; membrane raft; plasma membrane; proteinaceous extracellular matrix
Molecular Function: calcium ion binding; glycosaminoglycan binding; laminin-1 binding; morphogen activity; patched binding; peptidase activity; protein binding; zinc ion binding
Biological Process: androgen metabolic process; animal organ formation; axon guidance; Bergmann glial cell differentiation; blood coagulation; branching involved in blood vessel morphogenesis; branching involved in ureteric bud morphogenesis; branching morphogenesis of a tube; camera-type eye development; CD4-positive or CD8-positive, alpha-beta T cell lineage commitment; cell development; cell fate specification; cell-cell signaling; central nervous system development; dorsal/ventral neural tube patterning; dorsal/ventral pattern formation; ectoderm development; embryonic development; embryonic digestive tract morphogenesis; embryonic digit morphogenesis; embryonic foregut morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; embryonic pattern specification; embryonic skeletal system development; endocytosis; establishment of cell polarity; forebrain development; formation of anatomical boundary; granule cell precursor proliferation; hair follicle morphogenesis; heart development; heart looping; hindbrain development; hindgut morphogenesis; inner ear development; intein-mediated protein splicing; intermediate filament organization; limb bud formation; lung development; lymphoid progenitor cell differentiation; male genitalia development; metanephros development; midbrain development; myoblast differentiation; myotube differentiation; negative regulation of alpha-beta T cell differentiation; negative regulation of apoptosis; negative regulation of cell differentiation; negative regulation of cell migration; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of T cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative thymic T cell selection; neural crest cell migration; neuroblast proliferation; neuron fate commitment; odontogenesis of dentine-containing teeth; oligodendrocyte development; osteoblast development; palate development; pancreas development; pattern specification process; polarity specification of anterior/posterior axis; positive regulation of alpha-beta T cell differentiation; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of hh target transcription factor activity; positive regulation of immature T cell proliferation in the thymus; positive regulation of neuroblast proliferation; positive regulation of oligodendrocyte differentiation; positive regulation of protein import into nucleus; positive regulation of skeletal muscle cell proliferation; positive regulation of skeletal muscle tissue development; positive regulation of smoothened signaling pathway; positive regulation of striated muscle cell differentiation; positive regulation of T cell differentiation in thymus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; positive regulation of Wnt receptor signaling pathway; positive thymic T cell selection; prostate gland development; regulation of cell proliferation; regulation of odontogenesis; regulation of proteolysis; smoothened signaling pathway; smoothened signaling pathway in regulation of granule cell precursor cell proliferation; spinal cord dorsal/ventral patterning; spinal cord motor neuron differentiation; stem cell development; striated muscle tissue development; T cell differentiation in thymus; telencephalon regionalization; thalamus development; thymus development; thyroid gland development; vasculogenesis; ventral midline development; Wnt receptor signaling pathway through beta-catenin
Disease: Holoprosencephaly 3; Microphthalmia, Isolated, With Coloboma 5; Schizencephaly; Solitary Median Maxillary Central Incisor
Research Articles on SHHN
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Product Notes
The Rat SHHN shh (Catalog #AAA9908124) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9908124 ELISA Kit recognizes Rat SHHN. It is sometimes possible for the material contained within the vial of "Sonic Hedgehog N-Terminus (SHHN), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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