Rat Protein Kinase B Beta (PKBb) ELISA Kit | PKBb elisa kit
Rat Protein Kinase B Beta (PKBb) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
may be involved in phosphatidylinositol 3-kinase (PI3-K) mediated signaling [RGD, Feb 2006]
Uniprot Description
Akt2: an AGC kinase. Plays critical roles in glucose metabolism and the development or maintenance of proper adipose tissue and islet mass for which other Akt/PKB isoforms are unable to fully compensate. Amplified and overexpressed in human ovarian carcinoma cell lines and amplified in some primary ovarian and pancreatic tumors. Antisense blocks invasiveness in xenografts. Expressed in several insulin-responsive tissues, and one case of Type II diabetes has been associated with a likely LOF point mutation. Mouse mutants have defects in insulin response.
Protein type: Oncoprotein; EC 2.7.11.1; Protein kinase, AGC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); AGC group; AKT family
Cellular Component: nucleoplasm; intracellular membrane-bound organelle; plasma membrane; cell cortex; nucleus; cytosol; vesicle
Molecular Function: protein serine/threonine kinase activity; protein binding; protein kinase C binding; ATP binding; protein kinase activity
Biological Process: response to muscle activity; positive regulation of positive chemotaxis; positive regulation of nitric oxide biosynthetic process; multicellular organismal development; positive regulation of glycogen biosynthetic process; intracellular protein transport across a membrane; positive regulation of vesicle fusion; negative regulation of caspase activity; protein amino acid phosphorylation; response to insulin stimulus; regulation of translation; positive regulation of glucose import; negative regulation of RNA splicing; protein kinase B signaling cascade; response to nutrient levels; glycogen biosynthetic process; positive regulation of signal transduction; carbohydrate transport; myelin maintenance in the peripheral nervous system; glucose metabolic process; response to osmotic stress; positive regulation of peptidyl-serine phosphorylation; cellular response to hormone stimulus; positive regulation of fatty acid beta-oxidation; cellular response to insulin stimulus; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; negative regulation of apoptosis; positive regulation of cell migration
Research Articles on PKBb
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Product Notes
The Rat PKBb akt2 (Catalog #AAA9308838) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9308838 ELISA Kit recognizes Rat PKBb. It is sometimes possible for the material contained within the vial of "Protein Kinase B Beta (PKBb), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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