Rat Platelet-derived growth factor receptor-beta (PDGFRbeta) ELISA Kit | PDGFRbeta elisa kit
Rat Platelet-derived growth factor receptor-beta (PDGFRbeta) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Aug 2017]
Uniprot Description
PDGFRB: a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. The identity of the growth factor bound determines whether the functional receptor is a homodimer or a heterodimer, composed of both PDGFR-alpha and -beta. Ligand binding induces receptor dimerization and autophosphorylation, thereby recruiting SH2-containing proteins including Grb2, Src, GAP, PTPN11, PI3 kinase, PLC-gamma and Nck. Regulates cell growth, actin reorganization, migration and differentiation. A variety of myeloproliferative disorders and cancers result from translocations that activate PDGFRbeta by fusion with proteins such as TEL/ETV6, H2, CEV14/TRP11, rabaptin 5, and huntington interacting protein 1. Gleevec treatment of TEL fusions has been successful. Overexpressed in metastatic medulloblastoma. Inhibitors: Gleevec, Sutent.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; PDGFR family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 5q32
Cellular Component: apical plasma membrane; cell surface; cytoplasm; cytoplasmic vesicle; extracellular exosome; focal adhesion; integral component of membrane; intrinsic component of plasma membrane; lysosomal lumen; membrane; nucleus; plasma membrane
Molecular Function: ATP binding; enzyme binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphoinositide 3-kinase binding; platelet activating factor receptor activity; platelet-derived growth factor beta-receptor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; platelet-derived growth factor-activated receptor activity; protein binding; protein kinase binding; protein tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor binding; vascular endothelial growth factor binding
Biological Process: aging; cardiac myofibril assembly; cell migration; G-protein coupled receptor signaling pathway; glycosaminoglycan biosynthetic process; inner ear development; male gonad development; MAPK cascade; metanephric comma-shaped body morphogenesis; metanephric glomerular capillary formation; metanephric glomerular mesangial cell proliferation involved in metanephros development; metanephric mesenchyme development; metanephric S-shaped body morphogenesis; negative regulation of apoptosis; negative regulation of platelet-derived growth factor receptor-beta signaling pathway; peptidyl-tyrosine phosphorylation; phosphatidylinositol metabolic process; phosphatidylinositol phosphorylation; phosphoinositide-mediated signaling; platelet-derived growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of calcium ion import; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; positive regulation of chemotaxis; positive regulation of collagen biosynthetic process; positive regulation of DNA biosynthetic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of hepatic stellate cell activation; positive regulation of MAP kinase activity; positive regulation of mitotic nuclear division; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of phospholipase C activity; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein kinase B signaling; positive regulation of reactive oxygen species metabolic process; positive regulation of Rho protein signal transduction; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; protein autophosphorylation; regulation of actin cytoskeleton organization; response to estradiol; response to estrogen; response to hydrogen peroxide; response to hyperoxia; response to retinoic acid; response to toxin; signal transduction; smooth muscle cell chemotaxis; wound healing
Disease: Basal Ganglia Calcification, Idiopathic, 1; Basal Ganglia Calcification, Idiopathic, 4; Kosaki Overgrowth Syndrome; Myeloproliferative Disorder, Chronic, With Eosinophilia; Myofibromatosis, Infantile, 1; Premature Aging Syndrome, Penttinen Type
Research Articles on PDGFRbeta
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Product Notes
The Rat PDGFRbeta pdgfrb (Catalog #AAA2610711) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2610711 ELISA Kit recognizes Rat PDGFRbeta. It is sometimes possible for the material contained within the vial of "Platelet-derived growth factor receptor-beta (PDGFRbeta), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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