NCBI and Uniprot Product Information
Uniprot Description
NFL: one of the three (L, M, and H) intermediate filament proteins that form neurofilaments. Neurofilaments are involved in the maintenance of neuronal caliber. NF-L is the most abundant of the three neurofilament proteins. Defects cause Charcot-Marie-Tooth disease type 1F (CMT1F).
Protein type: Cytoskeletal
Cellular Component: TSC1-TSC2 complex; axon; neurofilament; intermediate filament
Molecular Function: protein C-terminus binding; protein binding, bridging; identical protein binding; structural constituent of cytoskeleton
Biological Process: neurofilament bundle assembly; intermediate filament organization; intermediate filament bundle assembly; microtubule cytoskeleton organization and biogenesis; retrograde axon cargo transport; axon regeneration in the peripheral nervous system; axon transport of mitochondrion; neurofilament cytoskeleton organization and biogenesis; regulation of axon diameter; positive regulation of axonogenesis; negative regulation of neuron apoptosis; neuromuscular process controlling balance; anterograde axon cargo transport; locomotion; neurite morphogenesis
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Product Notes
The Rat NEFL nefl (Catalog #AAA3809042) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA3809042 ELISA Kit recognizes Rat NEFL. It is sometimes possible for the material contained within the vial of "Neurofilament, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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