Western Blot (WB)
((10ug/ml) staining of Human renal cortical brush-border membrane lysate (90ug protein denatured at 37C for 30min) with (B) and without (A) blocking with the immunizing peptide. Primary incubation was overnight at 4C. Detected by NBT/BCIP. Data kindly provided by Dean Karaica, B. Sc. , and Ivan Sabolic, M. D. , Ph. D. , Institute for Medical Research and Occupational Health, Zagreb, Croatia.)
Goat SLC26A6 Polyclonal Antibody | anti-SLC26A6 antibody
Goat anti-SLC26A6 Antibody
Immunohistochemistry: In paraffin embedded Human Kidney showsstaining of brushborders along the entire proximal convoluted tubule. Recommended concentration, 0.1-0.3mg/ml. Please note the unusually low dilution required for this type of application!
Western Blot: Approx 90kDa band observed in Human renal cortical brush-border membrane lysates (calculated MW of 83. 0kDa according to NP_075062.2). Recommended concentration: 10ug/ml for overnight incubation.
Western Blot (WB)
((10ug/ml) staining of Human renal cortical brush-border membrane lysate (90ug protein denatured at 37C for 30min) with (B) and without (A) blocking with the immunizing peptide. Primary incubation was overnight at 4C. Detected by NBT/BCIP. Data kindly provided by Dean Karaica, B. Sc. , and Ivan Sabolic, M. D. , Ph. D. , Institute for Medical Research and Occupational Health, Zagreb, Croatia.)
Western Blot (WB)
((10ug/ml) staining of Human renal cortical brush-border membrane lysate (90ug protein denatured at 37C for 30min) with (B) and without (A) blocking with the immunizing peptide. Primary incubation was overnight at 4C. Detected by NBT/BCIP. Data kindly provided by Dean Karaica, B. Sc. , and Ivan Sabolic, M. D. , Ph. D. , Institute for Medical Research and Occupational Health, Zagreb, Croatia.)
Immunofluorescence (IF)
((0.1mg/ml) overnight staining of paraffin embedded Human Kidney. Microwaved antigen retrieval with citrate buffer pH 6, CY3-staining. Data kindly provided by Dean Karaica, B. Sc. , and Ivan Sabolic, M. D. , Ph. D. , Institute for Medical Research and Occupational Health, Zagreb, Croatia.)
Immunofluorescence (IF)
((0.1mg/ml) overnight staining of paraffin embedded Human Kidney. Microwaved antigen retrieval with citrate buffer pH 6, CY3-staining. Data kindly provided by Dean Karaica, B. Sc. , and Ivan Sabolic, M. D. , Ph. D. , Institute for Medical Research and Occupational Health, Zagreb, Croatia.)
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2013]
Uniprot Description
SLC26A6: Does not seem to be involved in anion transport. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Transporter; Transporter, SLC family; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3p21.3
Cellular Component: apical plasma membrane; basolateral plasma membrane; brush border membrane; cytoplasmic vesicle membrane; endoplasmic reticulum; integral to membrane; integral to plasma membrane; intracellular; membrane; plasma membrane; vesicle membrane
Molecular Function: anion:anion antiporter activity; bicarbonate transmembrane transporter activity; chloride channel activity; chloride transmembrane transporter activity; efflux transmembrane transporter activity; formate efflux transmembrane transporter activity; formate transmembrane transporter activity; formate uptake transmembrane transporter activity; inorganic anion exchanger activity; oxalate transmembrane transporter activity; PDZ domain binding; protein binding; secondary active sulfate transmembrane transporter activity; sulfate transmembrane transporter activity
Biological Process: bicarbonate transport; chloride transport; epithelial fluid transport; formate transport; intestinal absorption; intracellular pH elevation; ion transport; mannitol transport; oxalate transport; oxalic acid secretion; regulation of intracellular pH; regulation of membrane potential; sperm capacitation; sulfate transport; transepithelial chloride transport
Research Articles on SLC26A6
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Product Notes
The SLC26A6 slc26a6 (Catalog #AAA423035) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-SLC26A6 Antibody reacts with Tested: Human; Expected from sequence similarity: Human and may cross-react with other species as described in the data sheet. AAA Biotech's SLC26A6 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Peptide ELISA: Antibody detection limit dilution 1: 8000. Immunohistochemistry: In paraffin embedded Human Kidney showsstaining of brushborders along the entire proximal convoluted tubule. Recommended concentration, 0.1-0.3mg/ml. Please note the unusually low dilution required for this type of application! Western Blot: Approx 90kDa band observed in Human renal cortical brush-border membrane lysates (calculated MW of 83. 0kDa according to NP_075062.2). Recommended concentration: 10ug/ml for overnight incubation. Researchers should empirically determine the suitability of the SLC26A6 slc26a6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: SAPRTHQWRT. It is sometimes possible for the material contained within the vial of "SLC26A6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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