Rat Neuroendocrine secretory protein 55 (GNAS) ELISA Kit | GNAS elisa kit

Rat Neuroendocrine secretory protein 55 (GNAS) ELISA Kit

Cat. Num. AAA7231181

• Gene Names: GNAS; AHO; GSA; GSP; POH; GPSA; NESP; GNAS1; PHP1A; PHP1B; PHP1C; C20orf45
• Reactivity: Rat
• Synonyms: Neuroendocrine secretory protein 55 (GNAS); Rat Neuroendocrine secretory protein 55 (GNAS) ELISA Kit; GNAS elisa kit

• Reactivity: Rat

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Preparation and Storage: Store all reagents at 2-8 degree C.

Product Categories/Family for GNAS elisa kit

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 7532780
• NCBI GeneID: 2778
• Molecular Weight: 111,025 Da
• NCBI Official Full Name: neuroendocrine secretory protein 55
• NCBI Official Synonym Full Names: GNAS complex locus
• NCBI Official Symbol: GNAS
• NCBI Official Synonym Symbols: AHO; GSA; GSP; POH; GPSA; NESP; GNAS1; PHP1A; PHP1B; PHP1C; C20orf45
• NCBI Protein Information: protein ALEX; protein GNAS; protein NESP55; secretogranin VI; extra large alphas protein; neuroendocrine secretory protein; guanine nucleotide regulatory protein; alternative gene product encoded by XL-exon; adenylate cyclase-stimulating G alpha protein; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1
• UniProt Protein Name: Neuroendocrine secretory protein 55
• Protein Family: Neuroendocrine secretory protein
• UniProt Gene Name: GNAS
• UniProt Synonym Gene Names: GNAS1; NESP55
• UniProt Entry Name: GNAS3_HUMAN

NCBI Description

This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]

Uniprot Description

G-alpha(s) iso7: a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Agonist binding to Gq-coupled receptors may block Akt activation via the release of active G-alpha(q) subunits that inhibit phosphatidylinositol 3-kinase. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Protein type: Vesicle; Oncoprotein; G protein, heterotrimeric alpha G(s); G protein; G protein, heterotrimeric; Membrane protein, peripheral

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: ruffle; transport vesicle; membrane; perinuclear region of cytoplasm; cytoplasm; dendrite; extracellular region; plasma membrane; heterotrimeric G-protein complex; trans-Golgi network membrane; intrinsic to membrane; nucleus; cytosol

Molecular Function: GTPase activity; corticotropin-releasing hormone receptor 1 binding; GTP binding; metal ion binding; adenylate cyclase activity; insulin-like growth factor receptor binding; ionotropic glutamate receptor binding; protein binding; signal transducer activity; mu-type opioid receptor binding; G-protein beta/gamma-subunit binding; beta-2 adrenergic receptor binding; D1 dopamine receptor binding

Biological Process: developmental growth; positive regulation of osteoclast differentiation; water transport; protein secretion; female pregnancy; embryonic hindlimb morphogenesis; G-protein signaling, adenylate cyclase activating pathway; intracellular transport; positive regulation of cAMP biosynthetic process; DNA methylation; tissue homeostasis; transmembrane transport; post-embryonic body morphogenesis; dopamine receptor, adenylate cyclase activating pathway; endochondral ossification; response to drug; sensory perception of chemical stimulus; negative regulation of multicellular organism growth; multicellular organism growth; sensory perception of smell; adenylate cyclase activation; embryonic cranial skeleton morphogenesis; positive regulation of osteoblast differentiation; cartilage development; energy reserve metabolic process; renal water homeostasis; cAMP biosynthetic process; blood coagulation; cognition; regulation of insulin secretion

Disease: Osseous Heteroplasia, Progressive; Pseudopseudohypoparathyroidism; Pituitary Adenoma, Acth-secreting; Acth-independent Macronodular Adrenal Hyperplasia; Mccune-albright Syndrome; Pseudohypoparathyroidism, Type Ia; Pseudohypoparathyroidism, Type Ib; Pituitary Adenoma, Growth Hormone-secreting