anti-Human, Mouse CTRO Antibody | anti-CTRO antibody

CTRO Antibody

Cat. Num. AAA8509692

• Gene Names: CIT; CITK; CRIK; STK21; MCPH17
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Immunofluorescence, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: CTRO; CTRO Antibody; Citron Rho-interacting kinase; CRIK; Rho-interacting; serine/threonine-protein kinase 21; CIT; KIAA0949; STK21; anti-CTRO antibody

• Reactivity: Human, Mouse
• Specificity: CTRO antibody detects endogenous levels of total CTRO protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 2069

• Applicable Applications for anti-CTRO antibody: Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
• Application Notes: IHC: 1:50-1:100; IF: 1:100-1:500; ELISA: 1:40000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human CTRO.
• Preparation and Storage: Store at-20 degree C for 1 year.

Immunohistochemistry (IHC)

(Peptide-+ Immunohistochemistry analysis of paraffin-embedded human brain tissue using CTRO antibody.)

References

Nagase T., DNA Res. 6:63-70(1999). Scherer S.E., Nature 440:346-351(2006). Gruneberg U., J. Cell Biol. 172:363-372(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 332801082
• NCBI GeneID: 11113
• NCBI Accession #: NP_001193928.1
• NCBI GenBank Nucleotide #: NM_001206999.1
• UniProt Accession #: O14578; Q2M5E1; Q6XUH8; Q86UQ9; Q9UPZ7
• Molecular Weight: 236,607 Da
• NCBI Official Full Name: citron Rho-interacting kinase isoform 1
• NCBI Official Synonym Full Names: citron rho-interacting serine/threonine kinase
• NCBI Official Symbol: CIT
• NCBI Official Synonym Symbols: CITK; CRIK; STK21; MCPH17
• NCBI Protein Information: citron Rho-interacting kinase
• UniProt Protein Name: Citron Rho-interacting kinase
• UniProt Gene Name: CIT
• UniProt Synonym Gene Names: CRIK; KIAA0949; STK21; CRIK

NCBI Description

This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Uniprot Description

Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.