Rat Double-Strand Break Repair Protein MRE11A (MRE11A) ELISA Kit | MRE11A elisa kit
Rat Double-Strand Break Repair Protein MRE11A (MRE11A) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
MRE11A: a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Alternative splicing results in two different isoforms.
Protein type: Deoxyribonuclease; Cell cycle regulation; DNA-binding; DNA repair, damage
Chromosomal Location of Human Ortholog: 11q21
Cellular Component: chromosome, telomeric region; condensed nuclear chromosome; cytosol; Mre11 complex; nuclear chromatin; nuclear chromosome, telomeric region; nucleoplasm; nucleus; perinuclear region of cytoplasm; PML body
Molecular Function: 3'-5' exonuclease activity; ATP-dependent DNA helicase activity; DNA binding; double-stranded DNA binding; endodeoxyribonuclease activity; manganese ion binding; nuclease activity; protein binding; protein C-terminus binding; single-stranded DNA specific endodeoxyribonuclease activity
Biological Process: cell proliferation; DNA duplex unwinding; DNA recombination; DNA repair; double-strand break repair; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; double-strand break repair via synthesis-dependent strand annealing; heart development; innate immune response; intra-S DNA damage checkpoint; meiotic recombination; mitotic cell cycle G2/M transition DNA damage checkpoint; negative regulation of apoptosis; negative regulation of DNA endoreduplication; negative regulation of virion penetration into host cell; positive regulation of interferon type I production; positive regulation of kinase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of telomere maintenance; regulation of mitotic recombination; response to DNA damage stimulus; sister chromatid cohesion; synapsis; telomere maintenance via telomerase; telomeric 3' overhang formation; viral reproduction
Disease: Ataxia-telangiectasia-like Disorder 1
Research Articles on MRE11A
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Product Notes
The Rat MRE11A mre11a (Catalog #AAA9363205) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9363205 ELISA Kit recognizes Rat MRE11A. It is sometimes possible for the material contained within the vial of "Double-Strand Break Repair Protein MRE11A (MRE11A), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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