Rat Cleavage and polyadenylation specificity factor subunit 4 (CPSF4) ELISA Kit | CPSF4 elisa kit
Rat Cleavage and polyadenylation specificity factor subunit 4 (CPSF4) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
CPSF4: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U). Belongs to the CPSF4/YTH1 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA processing; Mitochondrial
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: nucleoplasm; mRNA cleavage and polyadenylation specificity factor complex
Molecular Function: zinc ion binding
Biological Process: modification by virus of host cellular process; virus-host interaction; modification by virus of host mRNA processing; viral infectious cycle; mRNA processing
Research Articles on CPSF4
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Product Notes
The Rat CPSF4 cpsf4 (Catalog #AAA7229457) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7229457 ELISA Kit recognizes Rat CPSF4. It is sometimes possible for the material contained within the vial of "Cleavage and polyadenylation specificity factor subunit 4 (CPSF4), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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