Rat CCR4-NOT transcription complex subunit 6 (CNOT6) ELISA Kit | CNOT6 elisa kit
Rat CCR4-NOT transcription complex subunit 6 (CNOT6) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a subunit of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substates. [provided by RefSeq, Jul 2008]
Uniprot Description
CNOT6: Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as general transcription regulation complex. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Belongs to the CCR4/nocturin family.
Protein type: Hydrolase; EC 3.1.13.4
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component: membrane; nucleus; cytosol; CCR4-NOT complex
Molecular Function: protein binding; poly(A)-specific ribonuclease activity; exoribonuclease activity; RNA binding; metal ion binding
Biological Process: regulation of translation; poly(A) tail shortening; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of cell proliferation; gene expression; miRNA-mediated gene silencing; mRNA catabolic process, deadenylation-dependent decay
Research Articles on CNOT6
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Product Notes
The Rat CNOT6 cnot6 (Catalog #AAA7236031) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7236031 ELISA Kit recognizes Rat CNOT6. It is sometimes possible for the material contained within the vial of "CCR4-NOT transcription complex subunit 6 (CNOT6), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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