Rat Cadherin EGF LAG seven-pass G-type receptor 1 (CELSR1) ELISA Kit | CELSR1 elisa kit
Rat Cadherin EGF LAG seven-pass G-type receptor 1 (CELSR1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008]
Uniprot Description
CELSR1: Receptor that may have an important role in cell/cell signaling during nervous system formation. Defects in CELSR1 are a cause of neural tube defects (NTD). NTD are congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 2
Chromosomal Location of Human Ortholog: 22q13.3
Cellular Component: nucleoplasm; integral to plasma membrane; plasma membrane; integral to membrane
Molecular Function: G-protein coupled receptor activity; protein dimerization activity; transmembrane receptor activity; calcium ion binding
Biological Process: inner ear morphogenesis; central nervous system development; wound healing; neuron migration; locomotory behavior; Rho protein signal transduction; establishment of polarity of embryonic epithelium; anterior/posterior pattern formation; G-protein coupled receptor protein signaling pathway; apical protein localization; hair follicle development; regulation of actin cytoskeleton organization and biogenesis; establishment of body hair orientation; neural tube closure; establishment of planar polarity; homophilic cell adhesion
Research Articles on CELSR1
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Product Notes
The Rat CELSR1 celsr1 (Catalog #AAA7234366) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7234366 ELISA Kit recognizes Rat CELSR1. It is sometimes possible for the material contained within the vial of "Cadherin EGF LAG seven-pass G-type receptor 1 (CELSR1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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