Western Blot (WB)
(Western blot analysis DENND4A using HT29 whole cell lysates)
Rabbit anti-Human DENND4A Polyclonal Antibody | anti-DENND4A antibody
DENND4A Antibody
Western Blot (WB)
(Western blot analysis DENND4A using HT29 whole cell lysates)
Western Blot (WB)
(Western blot analysis DENND4A using HT29 whole cell lysates)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a DENN domain-containing protein that may function as a guanine nucleotide exchange factor that specifically activates ras-related protein Rab-10. This protein also contains a interferon stimulated response element-binding domain and may be involved in regulating the v-myc avian myelocytomatosis viral (MYC) oncogene. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Mar 2016]
Uniprot Description
DENND4A: an ubiquitous nuclear guanine nucleotide exchange factor (GEF) that activates RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. Highest expression in fetal liver, bone marrow, medium in peripheral blood lymphocytes and lowest in spleen. Induced by serum in low-passage fibroblasts. Expressed at higher levels in normal cells (brain, breast, and prostate) than in tumor cells. Expression is regulated in a growth- and cell cycle-dependent manner. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; GEFs; GEFs, Rab
Chromosomal Location of Human Ortholog: 15q22.31
Molecular Function: Rab guanyl-nucleotide exchange factor activity
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Product Notes
The DENND4A dennd4a (Catalog #AAA9419288) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DENND4A Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DENND4A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:1000-3000. Researchers should empirically determine the suitability of the DENND4A dennd4a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DENND4A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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