Rat BAG6/Large Proline-Rich Protein BAG6 ELISA Kit | BAG6 elisa kit

Rat BAG6/Large Proline-Rich Protein BAG6 ELISA Kit

Cat. Num. AAA2890229

• Gene Names: Bag6; Bat3
• Reactivity: Rat
• Synonyms: BAG6/Large Proline-Rich Protein BAG6; Rat BAG6/Large Proline-Rich Protein BAG6 ELISA Kit; Large proline-rich protein BAG6; BCL2-associated athanogene 6; HLA-B-associated transcript 3; Bat3; BAG6 elisa kit

• Reactivity: Rat
• Specificity: Natural and recombinant Rat Large proline-rich protein BAG6
• Sequence Length: 1146

• Assay Type: Sandwich
• Detection Range: 0.312-20ng/mL
• Sensitivity: 0.156ng/mL
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 77020274
• NCBI GeneID: 94342
• NCBI Accession #: NP_001029140.1
• NCBI GenBank Nucleotide #: NM_001033968.1
• UniProt Accession #: Q6MG49
• NCBI Official Full Name: large proline-rich protein BAG6 isoform 1
• NCBI Official Synonym Full Names: BCL2-associated athanogene 6
• NCBI Official Symbol: Bag6
• NCBI Official Synonym Symbols: Bat3
• NCBI Protein Information: large proline-rich protein BAG6
• UniProt Protein Name: Large proline-rich protein BAG6
• Protein Family: BAG family molecular chaperone regulator
• UniProt Gene Name: Bag6

Uniprot Description

ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome. SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome. BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate to the production of antigenic peptides and play a role in antigen presentation in immune response. BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress. By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis. Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1.