Rat Adenosine Receptor A1 ELISA Kit | ADORA1 elisa kit

Rat Adenosine Receptor A1 ELISA Kit

Cat. Num. AAA3808765

• Gene Names: ADORA1; RDC7
• Reactivity: Rat
• Synonyms: Adenosine Receptor A1; Rat Adenosine Receptor A1 ELISA Kit; ADORA1 elisa kit

• Reactivity: Rat
• Sequence Length: 326

• Samples: Serum, plasma, cell culture supernate and other biological fluids
• Assay Type: Sandwich
• Detection Range: 0.5ng/ml-8ng/ml
• Sensitivity: 0.1 ng/ml

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for ADORA1 elisa kit

Intended Use: The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofADENOSINE RECEPTOR A1in the sample, This ADENOSINE RECEPTOR A1ELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versusADENOSINE RECEPTOR A1concentration. The concentration ofADENOSINE RECEPTOR A1in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 4501947
• NCBI GeneID: 134
• NCBI Accession #: NP_000665
• NCBI GenBank Nucleotide #: NP_000665.1
• UniProt Accession #: P30542
• NCBI Official Full Name: adenosine receptor A1 isoform 1
• NCBI Official Synonym Full Names: adenosine A1 receptor
• NCBI Official Symbol: ADORA1
• NCBI Official Synonym Symbols: RDC7
• NCBI Protein Information: adenosine receptor A1
• UniProt Protein Name: Adenosine receptor A1
• Protein Family: Adenosine receptor
• UniProt Gene Name: ADORA1
• UniProt Entry Name: AA1R_HUMAN

NCBI Description

The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

ADORA1: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Apoptosis; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: asymmetric synapse; presynaptic membrane; postsynaptic membrane; cell soma; endoplasmic reticulum; basolateral plasma membrane; integral to plasma membrane; postsynaptic density; presynaptic active zone; plasma membrane; dendritic spine; terminal button; axolemma

Molecular Function: protein binding; G-protein-coupled receptor binding; protein heterodimerization activity; G-protein beta/gamma-subunit binding; purine nucleoside binding; adenosine receptor activity, G-protein coupled; phospholipase C activity; heterotrimeric G-protein binding

Biological Process: negative regulation of circadian sleep/wake cycle, non-REM sleep; relaxation of vascular smooth muscle; activation of MAPKK activity; negative regulation of glutamate secretion; negative regulation of hormone secretion; positive regulation of potassium ion transport; regulation of synaptic plasticity; positive regulation of peptide secretion; neurological control of breathing; thermoregulation; signal transduction; positive regulation of protein amino acid dephosphorylation; negative regulation of cell proliferation; regulation of glomerular filtration; cell-cell signaling; positive regulation of nucleoside transport; positive regulation of epidermal growth factor receptor activity; negative regulation of lipid catabolic process; negative regulation of vasodilation; negative regulation of blood pressure; detection of temperature stimulus involved in sensory perception of pain; protein targeting to membrane; inflammatory response; negative regulation of synaptic transmission, GABAergic; adenosine receptor signaling pathway; nervous system development; negative regulation of neurotrophin production; negative regulation of synaptic transmission, glutamatergic; negative regulation of acute inflammatory response; negative regulation of leukocyte migration; phagocytosis; response to hypoxia; G-protein signaling, adenylate cyclase inhibiting pathway; regulation of sensory perception of pain; regulation of excitatory postsynaptic membrane potential; cognition; positive regulation of blood pressure; lipid catabolic process; negative regulation of apoptosis