Rat A Disintegrin And Metalloprotease 17 (ADAM17) ELISA Kit | ADAM17 elisa kit

Rat A Disintegrin And Metalloprotease 17 (ADAM17) ELISA Kit

Cat. Num. AAA452317

• Gene Names: Adam17; TACE
• Reactivity: Rat
• Synonyms: A Disintegrin And Metalloprotease 17 (ADAM17); Rat A Disintegrin And Metalloprotease 17 (ADAM17) ELISA Kit; CD156b; TACE; CSVP; Tumor Necrosis Factor; Alpha; Converting Enzyme; Disintegrin and metalloproteinase domain-containing protein 17; Snake venom-like protease; ADAM17 elisa kit

• Reactivity: Rat
• Sequence Length: 827

• Samples: Tissue homogenates, cell lysates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 0.312-20ng/mL
• Sensitivity: 0.112ng/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 9945330
• NCBI GeneID: 57027
• NCBI Accession #: NP_064702.1
• NCBI GenBank Nucleotide #: NM_020306.2
• UniProt Accession #: Q9Z1K9
• Molecular Weight: 93,017 Da
• NCBI Official Full Name: disintegrin and metalloproteinase domain-containing protein 17
• NCBI Official Synonym Full Names: ADAM metallopeptidase domain 17
• NCBI Official Symbol: Adam17
• NCBI Official Synonym Symbols: TACE
• NCBI Protein Information: disintegrin and metalloproteinase domain-containing protein 17
• UniProt Protein Name: Disintegrin and metalloproteinase domain-containing protein 17
• Protein Family: Disintegrin and metalloproteinase domain-containing protein
• UniProt Gene Name: Adam17
• UniProt Synonym Gene Names: Tace; ADAM 17

NCBI Description

expression occurs in response to oxygen glucose deprivation, may play a role in inhibition of apoptosis via induction of TNF-alpha release [RGD, Feb 2006]

Uniprot Description

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2 ().