Ras-specific guanine nucleotide-releasing factor 2 (RASGRF2) Recombinant Protein | RASGRF2 recombinant protein

Recombinant Human Ras-specific guanine nucleotide-releasing factor 2 (RASGRF2) , partial

• Gene Names: RASGRF2; GRF2; RAS-GRF2
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ras-specific guanine nucleotide-releasing factor 2 (RASGRF2); Recombinant Human Ras-specific guanine nucleotide-releasing factor 2 (RASGRF2); partial; RASGRF2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,237

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 38505170
• NCBI GeneID: 5924
• NCBI Accession #: NP_008840.1
• NCBI GenBank Nucleotide #: NM_006909.2
• UniProt Accession #: O14827; Q9UK56; B9EG89
• Molecular Weight: 140,764 Da
• NCBI Official Full Name: ras-specific guanine nucleotide-releasing factor 2
• NCBI Official Synonym Full Names: Ras protein specific guanine nucleotide releasing factor 2
• NCBI Official Symbol: RASGRF2
• NCBI Official Synonym Symbols: GRF2; RAS-GRF2
• NCBI Protein Information: ras-specific guanine nucleotide-releasing factor 2
• UniProt Protein Name: Ras-specific guanine nucleotide-releasing factor 2
• Protein Family: Ras-specific guanine nucleotide-releasing factor
• UniProt Gene Name: RASGRF2
• UniProt Synonym Gene Names: GRF2; Ras-GRF2

NCBI Description

RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011]

Uniprot Description

Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation.