Receptor activity-modifying protein 2 Recombinant Protein | RAMP2 recombinant protein
Receptor activity-modifying protein 2
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008]
Uniprot Description
RAMP2: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. Belongs to the RAMP family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q12-q21.1
Cellular Component: cell surface; coated pit; cytoplasm; integral to plasma membrane; lysosome; plasma membrane; receptor complex
Molecular Function: coreceptor activity; protein binding; protein transporter activity
Biological Process: angiogenesis; calcium ion transport; cAMP biosynthetic process; heart development; negative regulation of vascular permeability; positive regulation of angiogenesis; positive regulation of cAMP biosynthetic process; protein transport; receptor internalization; regulation of blood pressure; sprouting angiogenesis; vasculogenesis
Research Articles on RAMP2
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Product Notes
The RAMP2 ramp2 (Catalog #AAA7043245) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 43-175aa; full length protein. The amino acid sequence is listed below: QPLPTTGTPG SEGGTVKNYE TAVQFCWNHY KDQMDPIEKD WCDWAMISRP YSTLRDCLEH FAELFDLGFP NPLAERIIFE THQIHFANCS LVQPTFSDPP EDVLLAMIIA PICLIPFLIT LVVWRSKDSE AQA. It is sometimes possible for the material contained within the vial of "Receptor activity-modifying protein 2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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