Receptor activity-modifying protein 1 (RAMP1) Recombinant Protein | RAMP1 recombinant protein

Recombinant Human Receptor activity-modifying protein 1 (RAMP1)

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Receptor activity-modifying protein 1 (RAMP1); Recombinant Human Receptor activity-modifying protein 1 (RAMP1); Receptor activity-modifying protein 1; Calcitonin-receptor-like receptor activity-modifying protein 1; CRLR activity-modifying protein 1; RAMP1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 27-117
• Sequence: CQEA NYGALLRELC LTQFQVDMEA VGETLWCDWG RTIRSYRELA DCTWHMAEKL GCFWPNAEVD RFFLAVHGRY FRSCPISGRA VRDPPGS
• Sequence Length: 91

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 5032019
• NCBI GeneID: 10267
• NCBI Accession #: NP_005846.1
• NCBI GenBank Nucleotide #: NM_005855.2
• UniProt Accession #: O60894; Q6FGS5
• Molecular Weight: 16,988 Da
• NCBI Official Full Name: receptor activity-modifying protein 1
• NCBI Official Synonym Full Names: receptor (G protein-coupled) activity modifying protein 1
• NCBI Official Symbol: RAMP1
• NCBI Protein Information: receptor activity-modifying protein 1; CRLR activity-modifying protein 1; receptor activity modifying protein 1; receptor (calcitonin) activity modifying protein 1; calcitonin receptor-like receptor activity modifying protein 1; calcitonin-receptor-like receptor activity-modifying protein 1
• UniProt Protein Name: Receptor activity-modifying protein 1
• Protein Family: Receptor activity-modifying protein
• UniProt Gene Name: RAMP1
• UniProt Synonym Gene Names: CRLR activity-modifying protein 1
• UniProt Entry Name: RAMP1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. [provided by RefSeq, Jul 2008]

Uniprot Description

RAMP1: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL. Belongs to the RAMP family.

Protein type: Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 2q36-q37.1

Cellular Component: extracellular space; cell surface; integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: protein binding; calcitonin receptor binding; coreceptor activity; receptor activity; protein transporter activity; calcitonin receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; intracellular protein transport; protein transport; positive regulation of protein amino acid glycosylation; calcium ion transport; receptor internalization; positive regulation of cAMP biosynthetic process; angiogenesis; regulation of G-protein coupled receptor protein signaling pathway